Organometallics as Catalysts in the Fine Chemical Industry

• Johannes G. de Vries: Pd-catalyzed coupling reactions.- Gregory T. Whiteker and Christopher J. Cobley: Applications of Rhodium-Catalyzed Hydroformylation in the Pharmaceutical, Agrochemical and Fragrance Industries.- Philippe Dupau: Ruthenium-catalyzed Selective Hydrogenation for Flavor and Fragrance Applications.- Hans-Ulrich Blaser, Benoît Pugin and Felix Spindler: Asymmetric Hydrogenation.- Ioannis Houpis: Case Study: Sequential Pd-catalyzed Cross-Coupling Reactions; Challenges on Scale-up.- Adriano F. Indolese: Pilot Plant Scale Synthesis of an Aryl-Indole - Scale up of a Suzuki Coupling.- Per Ryberg: Development of a Mild and Robust Method for Palladium Catalysed Cyanation on Large Scale.- Cheng-yi Chen: Application of Ring Closing Metathesis Strategy to the Synthesis of Vaniprevir (MK-7009), a 20-Membered Macrocyclic HCV Protease Inhibitor.

From the reviews:“‘Organometallics as Catalysts in the Fine Chemical Industry’, presents the state-of-the-art in the industrial use of organometallic or coordination complexes as catalysts for the production of fine chemicals. … a helpful source of information for specialists in the field of organometallic catalysis, as well as beginners who have just entered the field or intend to do so. … this book may also serve as a valuable source of information not only for research purposes, but also for students and colleagues teaching organometallic catalysis.” (Michel Picquet, Platinum Metals Review, Vol. 57 (4), 2013)