Organic Nanomaterials for Cancer Phototheranostics

Häftad, Engelska, 2023

Av Manzar Abbas, Atia Atiq, Muhammad Ovais, Michael R Hamblin

2 799 kr

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Organic Nanomaterials for Cancer Phototheranostics highlights the use of biocompatible building blocks to make nanomaterials that can aid in medical treatment through better diagnostic and antitumor efficacy. The book synthesizes the current literature on synthetic strategies and designs based on peptides, proteins, polymers, lipids, and their conjugates, as well as composites and complexes with metals and inorganic components used to form the nanomaterials. Mechanistic approaches, clinical problems, and therapeutic and diagnostics mechanisms are covered in each chapter. Cellular interactions and uptake, pharmacokinetics, biodistribution, drug delivery efficiency, and safety concerns of these types of nanomaterials are also discussed. Other topics cover photostability, clearance, metabolism, in-vitro and in-vivo mechanisms, therapeutic efficacy, imaging, and toxicology.

Outlines fabrication and design strategies of peptides, proteins, polymers, lipids, composites, and complexes with metals and inorganic components
Discusses the limitations and challenges of organic nanomaterials in clinical use, including their mechanisms of penetration into cancer cells and tissue, photostability, clearance, and metabolism
Covers clinical problems and therapeutic and diagnostics mechanisms

Produktinformation

Utgivningsdatum2023-08-31
Mått152 x 229 x 19 mm
Vikt1 000 g
FormatHäftad
SpråkEngelska
SerieWoodhead Publishing Series in Biomaterials
Antal sidor272
FörlagElsevier Science
ISBN9780323957588

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Dr. Abbas started working as an assistant professor of chemistry at Khalifa University of Science and Technology, Abu Dhabi, UAE in 2022. He holds a Ph.D. degree in material chemistry from the Institute of Process Engineering, Chinese Academy of Sciences, Beijing, China. After graduating in 2017, he was a post-doctoral researcher at King Abdullah University of Science and Technology, Saudi Arabia. Later in 2019, he was awarded the Marie Curie Individual Fellowship from European Foundation and he joined the Institute for Molecules and Materials at Radboud University, Netherlands. By training, he is a chemist with work experience in organic synthesis, peptide chemistry, and material science with a focus on the multidisciplinary cutting-edge research direction in advanced drug delivery, and synthetic cells. He is the recipient of the 2017 UCAS Excellent International Graduate award and has published high-impact articles in peer-reviewed journals like the Journal of American Chemical Society/ACS, Nature Chemistry, Advanced Materials-Wiley, and Chemical Society Review/RSC. His group research is focused on the design and synthesis of small functional molecules including short peptides, and self-assembled nano-micro level materials for anticancer and protocell applications. His research work has been cited over 1900 times and he is serving as guest editor for a joint special collection on “peptide-based supramolecular systems in Chemistry – A European Journal, ChemBioChem, and Journal of Peptide Science for Wiley-VCH publisher. He is an active reviewer for reputed journals including Nano Today, Advanced Science, ChemBioChem, Chemistry-An Asian Journal, and Colloid and Surfaces A; Physicochemical and Engineering Aspects. Dr. Atiq completed her Ph.D. in physics in 2019 from the Institute of Physics, The Islamia University of Bahawalpur, Pakistan. She is currently working as an Assistant Professor in the Multan campus of the University of Education, Lahore, Pakistan. Her research interests are nanomaterials for biomedical applications, photon dose calculations, treatment planning, and quality assurance programs in radiotherapy. Muhammad Ovais is a Research Scientist at the CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center of Excellence in Nanoscience, National Center for Nanoscience and Technology (NCNST), China. His research focuses on nanomedicine and cancer theranostics.Dr. Ovais received his Ph.D. with distinction from CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China. His research interests are in nanomedicines, biomaterials, immuno-engineering, and nanocatalytic medicine. He is the recipient of over 30 international awards, has authored over 50 journal articles and book chapters in journals such as Advanced Materials, NanoToday, Nanomedicine-Future Medicine, and Science China Chemistry. Michael Hamblin was a Principal Investigator at the Wellman Center for Photomedicine at Massachusetts General Hospital, and Associate Professor of Dermatology, Harvard Medical School. He is now a Visiting Professor at the University of Johannesburg, South Africa. His research interests include photodynamic therapy and photobiomodulation. He has published more than 530 peer-reviewed articles and 25 textbooks. His work has been cited more than 49k times and he is Editor-in-Chief of Photobiomodulation, Photomedicine, and Laser Surgery.

1. Contemporary developments, trends, and challenges in cancer phototheranostics2. The role of nanotechnology: Organic nanomaterials and the mechanism of cancer phototheranostics3. Synthetic strategies of short peptide-modified nanomaterials for diagnostics and phototherapy4. Development of metal–peptide composite nanomaterials for diagnosis and phototherapy5. Fabrication of protein-based nanomaterials as photonanomedicine agents6. Synthetic strategies of protein–metal nanomaterials as photonanomedicine agents7. Fabrication of polymeric nanomaterials for phototheranostics of cancer8. Development of metal–polymer composite nanomaterials for diagnosis and phototherapy9. Lipid-based nanomaterials as phototheranostic agents10. Safety considerations of organic nanomaterials for phototheranostics