Dr Jiapu Zhang received bachelor degree in 1993, first master degree in research in 1996, both from Qufu Normal University, P.R. China; second master degree in research in 2000 from National University of Singapore, Republic of Singapore; a PhD degree in 2005 from Federation University, Australia; and then a formal postdoctoral fellowship training from CSIRO (Commonwealth Scientific and Industrial Research Organisation), Australia. Dr Zhang also received honors in Australia and worldwide for his prion research. In 2011, the report of MIT (Massachusetts Institute of Technology) Technology Review on his prion results caused worldwide impacts so that several organizations (e.g., the Physics Society of Iran) published his prion results in seven languages. NHMRC (National Health and Medical Research Council) of Australia has assigned him review tasks on prion projects. CSIRO once conferred him an award (together with Drs. Varghese JN and Epa VC) for rabbit prion protein research. He has been a reviewer for many top academic journals (e.g., Nature). All these made Dr. Zhang feel honored for his prion research.

• 1 Papain-Like cysteine protease (PLpro).- 2 3C-Like protease (3CLpro).- 3 RNA-dependent RNA polymerase (RdRp).- 4 RNA-helicase.- 5 RNA-helicase binding with [RdRp, NSP7, NSP8a, NSP8b, pRNA, tRNA, ADP-Mg2+, ATP-Mg2+].- 6 RNA-helicase binding with [ADP-Mg2+, ATP-Mg2+, and RNA].- 7 Spike (S) glycoprotein.- 8 Spike (S) glycoprotein D614G mutant.- 9 Spike (S) glycoprotein N501Y mutant.- 10 Spike (S) glycoprotein N165A-and-N234A mutant.- 11 SARS (SARS-CoV-1).- 12 MERS-coronavirus (MERS).- 13 Human-ACE2, human-L6, human-L6R, human-nAChRs.- 14 PLpro binding with 12 compounds.- 15 3CLpro binding with N3/Lopinavir/Ritonavir.- 16 3CLpro dimer binding with 7 HIV-inhibitors and Others.- 17 Spike RBDs binding with 50 drugs.- 18 Human ACE2 ectodomain binding with 78 drugs.- 19 Spike-and-ACE2 binding with 100 drugs.- 20 Envelope protein (E-protein).- 21 Membrane glycoprotein (M-protein).- 22 Nucleocapsid phosphoprotein (N-protein).- 23 SARS-CoV-2 RNA genome.- 24 NSP7, NSP8, NSP9, NSP10, NSP16, NSP14.- 25 NSP15.- 26 Other mutants.- 27 Vaccines and Drugs.- 28 Pandemic Mathematical Models, Epidemiology and Virus Origins.- A Mathematical Optimization Algorithms and Free Energy Calculations.- References.- Index.

“The book is presented in 28 chapters, plus a short appendix on MD optimization algorithms, references, and an index. … Each chapter begins with a brief introduction in which the central substances are presented … . Several of these chapters are followed by a lengthy supplemental section with many more tables of data results selected from the MD trajectories plus additional small graphics. The number and length of the tables is overwhelming.” (Anthony J. Duben, Computing Reviews, May 26, 2025)

Dr Jiapu Zhang received bachelor degree in 1993, first master degree in research in 1996, both from Qufu Normal University, P.R. China; second master degree in research in 2000 from National University of Singapore, Republic of Singapore; a PhD degree in 2005 from Federation University, Australia; and then a formal postdoctoral fellowship training from CSIRO (Commonwealth Scientific and Industrial Research Organisation), Australia. Dr Zhang also received honors in Australia and worldwide for his prion research. In 2011, the report of MIT (Massachusetts Institute of Technology) Technology Review on his prion results caused worldwide impacts so that several organizations (e.g., the Physics Society of Iran) published his prion results in seven languages. NHMRC (National Health and Medical Research Council) of Australia has assigned him review tasks on prion projects. CSIRO once conferred him an award (together with Drs. Varghese JN and Epa VC) for rabbit prion protein research. He has been a reviewer for many top academic journals (e.g., Nature). All these made Dr. Zhang feel honored for his prion research.

• 1 Papain-Like cysteine protease (PLpro).- 2 3C-Like protease (3CLpro).- 3 RNA-dependent RNA polymerase (RdRp).- 4 RNA-helicase.- 5 RNA-helicase binding with [RdRp, NSP7, NSP8a, NSP8b, pRNA, tRNA, ADP-Mg2+, ATP-Mg2+].- 6 RNA-helicase binding with [ADP-Mg2+, ATP-Mg2+, and RNA].- 7 Spike (S) glycoprotein.- 8 Spike (S) glycoprotein D614G mutant.- 9 Spike (S) glycoprotein N501Y mutant.- 10 Spike (S) glycoprotein N165A-and-N234A mutant.- 11 SARS (SARS-CoV-1).- 12 MERS-coronavirus (MERS).- 13 Human-ACE2, human-L6, human-L6R, human-nAChRs.- 14 PLpro binding with 12 compounds.- 15 3CLpro binding with N3/Lopinavir/Ritonavir.- 16 3CLpro dimer binding with 7 HIV-inhibitors and Others.- 17 Spike RBDs binding with 50 drugs.- 18 Human ACE2 ectodomain binding with 78 drugs.- 19 Spike-and-ACE2 binding with 100 drugs.- 20 Envelope protein (E-protein).- 21 Membrane glycoprotein (M-protein).- 22 Nucleocapsid phosphoprotein (N-protein).- 23 SARS-CoV-2 RNA genome.- 24 NSP7, NSP8, NSP9, NSP10, NSP16, NSP14.- 25 NSP15.- 26 Other mutants.- 27 Vaccines and Drugs.- 28 Pandemic Mathematical Models, Epidemiology and Virus Origins.- A Mathematical Optimization Algorithms and Free Energy Calculations.- References.- Index.

“The book is presented in 28 chapters, plus a short appendix on MD optimization algorithms, references, and an index. … Each chapter begins with a brief introduction in which the central substances are presented … . Several of these chapters are followed by a lengthy supplemental section with many more tables of data results selected from the MD trajectories plus additional small graphics. The number and length of the tables is overwhelming.” (Anthony J. Duben, Computing Reviews, May 26, 2025)

Dr Jiapu Zhang received bachelor degree in 1993, first master degree in research in 1996, both from Qufu Normal University, P.R. China; second master degree in research in 2000 from National University of Singapore, Republic of Singapore; a PhD degree in 2005 from Federation University, Australia; and then a formal postdoctoral fellowship training from CSIRO (Commonwealth Scientific and Industrial Research Organisation), Australia. Dr Zhang also received honors in Australia and worldwide for his prion research. In 2011, the report of MIT (Massachusetts Institute of Technology) Technology Review on his prion results caused worldwide impacts so that several organizations (e.g., the Physics Society of Iran) published his prion results in seven languages. NHMRC (National Health and Medical Research Council) of Australia has assigned him review tasks on prion projects. CSIRO once conferred him an award (together with Drs. Varghese JN and Epa VC) for rabbit prion protein research. He has been a reviewer for many top academic journals (e.g., Nature). All these made Dr. Zhang feel honored for his prion research.

• 1 Papain-Like cysteine protease (PLpro).- 2 3C-Like protease (3CLpro).- 3 RNA-dependent RNA polymerase (RdRp).- 4 RNA-helicase.- 5 RNA-helicase binding with [RdRp, NSP7, NSP8a, NSP8b, pRNA, tRNA, ADP-Mg2+, ATP-Mg2+].- 6 RNA-helicase binding with [ADP-Mg2+, ATP-Mg2+, and RNA].- 7 Spike (S) glycoprotein.- 8 Spike (S) glycoprotein D614G mutant.- 9 Spike (S) glycoprotein N501Y mutant.- 10 Spike (S) glycoprotein N165A-and-N234A mutant.- 11 SARS (SARS-CoV-1).- 12 MERS-coronavirus (MERS).- 13 Human-ACE2, human-L6, human-L6R, human-nAChRs.- 14 PLpro binding with 12 compounds.- 15 3CLpro binding with N3/Lopinavir/Ritonavir.- 16 3CLpro dimer binding with 7 HIV-inhibitors and Others.- 17 Spike RBDs binding with 50 drugs.- 18 Human ACE2 ectodomain binding with 78 drugs.- 19 Spike-and-ACE2 binding with 100 drugs.- 20 Envelope protein (E-protein).- 21 Membrane glycoprotein (M-protein).- 22 Nucleocapsid phosphoprotein (N-protein).- 23 SARS-CoV-2 RNA genome.- 24 NSP7, NSP8, NSP9, NSP10, NSP16, NSP14.- 25 NSP15.- 26 Other mutants.- 27 Vaccines and Drugs.- 28 Pandemic Mathematical Models, Epidemiology and Virus Origins.- A Mathematical Optimization Algorithms and Free Energy Calculations.- References.- Index.

“The book is presented in 28 chapters, plus a short appendix on MD optimization algorithms, references, and an index. … Each chapter begins with a brief introduction in which the central substances are presented … . Several of these chapters are followed by a lengthy supplemental section with many more tables of data results selected from the MD trajectories plus additional small graphics. The number and length of the tables is overwhelming.” (Anthony J. Duben, Computing Reviews, May 26, 2025)