Christopher Pittenger is Director of the Yale OCD Research Clinic and Associate Professor of Psychiatry at Yale University. He trained at Columbia University, where he both received his medical degree and completed his Ph.D. with Nobel Prize winner Eric Kandel. He then completed his clinical training in psychiatry at Yale, where he joined the faculty in 2007. Dr. Pittenger lives outside New Haven, CT, with his wife, four children, three cats, and six chickens.

• 1. Introduction: Narratives of OCD - Elias Aboujaoude and Christopher PittengerSection 1: Clinical Presentation and Diagnosis2. Clinical Presentation of OCD - Fred Penzel3. Pediatric OCD: Clinical Course, Phenomology, and Assessment - Rachel E. Ginsberg, Samantha Morrison, and Anthony Puliafico4. Epidemiology, Comorbidity, and Burden of OCD - Albina R. Torres, Leonardo F. Fontenelle, Roseli G. Shavitt, Marcelo Q. Hoexter, Christopher Pittenger, and Euripedes C. Miguel5. Natural History and Long-Term Outcome of OCD - Michael H. Bloch6. Quality of Life and Psychosocial Functioning in OCD - Christina L. Boisseau, Carly M. Schwartzman, and Steven A. Rasmussen7. Psychodynamic perspectives on OCD - Robert A. KingSection 2: Phenomenology and Cognitive Psychology8. Symptom heterogeneity in OCD: A dimensional approach - Maria Concei Conceição do Rosário, Marcelo Batistutto, and Ygor Ferrao9. Incompleteness and harm avoidance - Stefano Pallanti, Jennifer Barnes, Christopher Pittenger, and Jane Eisen10. Disgust and OCD - Lauren Mancusi & Dean McKay11. Sensory Processing and Intolerance in OCD - Stephanie J. Grimaldi, and Emily R. Stern12. Scrupulosity and Slowness in OCD: Perfectionism as a Central Mechanism - Rachel Ojserkis and Dean McKay13. Variable Insight in OCD - Rebecca J. Hamblin, Jennifer Moonjung Park, Monica S. Wu, and Eric A. Storch14. Clinical Rating Scales for OCD - Joseph F. McGuire, Eric A. Storch, and Wayne Goodman15. Neuropsychosocial Function in OCD - Amitai Abramovitch16. Habits and Goals in OCD - Claire M. Gillan17. Intolerance of Uncertainty in Obsessive-Compulsive Disorder - Ryan J. Jacoby and Jonathan S. Abramowitz18. Pathological responsibility, thought-action fusion, and thought control in OCD - Christine PurdonSection 3: Biological Underpinnings19. Genetics Of OCD - Paul Arnold20. Neurocircuitry underlying OCD : neural networks underlying reward and action selection - Suzanne N. Haber21. A review and synthesis of functional neuroimaging studies of OCD - Brian P. Brennan and Scott L. Rauch22. Functional Imaging Studies of OCD: A Hypothesis-Driven Review - M.M. Vaghi and T.W. Robbins23. The Structure of the OCD Brain - Premika S.W. Boedhoe and Odile A. van den Heuvel24. Brain Functional Connectivity in OCD - Carles Soriano-Mas and Ben J. Harrison25. Neurotransmitter dysregulation in OCD - Ilse Graat, Martijn Figee, and Damiaan Denys26. Neuropeptides in OCD - Anahid Kabasakalian, Eric Hollander27. Influence of sex hormones on OCD - Valeria Guglielmi, Judith Souget, Wouter van Elzelingen, Ingo Willuhn, and Nienke Vulink28. PANDAS as a Post-Streptococcal Autoimmune Neuropsychiatric Form of OCD - Susan E. Swedo, Kyle A. WiliamsSection 4: Animal Studies29. Animal models of OCD: A conceptual framework - Christopher Pittenger, Stephanie Dulawa, and Summer L. Thompson30. Extinction of conditioned fear and avoidance: Relevance for OCD - Jose Rodriguez-Romaguera and Gregory J. Quirk31. OCD as a failure to integrate goal-directed and habitual action control - Laura Bradfield, Richard Morris, and Bernard W. Balleine32. Spontaneously Occurring Animal Models of OCD - Nicholas H. Dodman and Louis Shuster33. Mutant Mouse Models of OCD - Louis Y. Tee and Guoping Feng34. Targeted circuit manipulations in the modeling of OCD - Susanne E. Ahmari35. Pharmacological and behavioral rodent models of OCD - Summer L. Thompson and Stephanie C. DulawaSection 5: Treatment36. Overview of the treatment of OCD - H. Blair Simpson37. Exposure and Response Prevention in OCD - Jonathan S. Abramowitz38. Cognitive Therapy for OCD - Maureen Whittal39. Mindfulness and Acceptance Therapies for Obsessive-Compulsive and Related Disorders - Kate L. Morrison, Brooke M. Smith, and Michael P. Twohig40. Standard Evidence-Based Pharmacological Treatment for OCD - Jemma E. Reid, Samar Reghunandanan, Ann Roberts, and Naomi A. Fineberg41. The pharmacological treatment of refractory OCD - Christopher Pittenger42. Treatment of Pediatric OCD - S. Evelyn Stewart and Clare Bleakley43. Family accommodation in OCD: Prevalence, impact, and clinical implications - Kristin Koller and Eli R. Lebowitz44. Nutraceutical and alternative treatments for Obsessive compulsive and Related Disorders - David Camfield and Jerome Sarris45. Functional Neurosurgery in Severe and Treatment-Refractory OCD - Erica C. Keen, Alik S. Widge, and Darin D. Dougherty46. Deep Brain Stimulation for Intractable OCD - Wayne K. Goodman, Nigel Kennedy, Kyle Lapidus, and Brian H. Kopell47. Intensive Treatment Approaches for OCD - Joshua M. Nadeau, Bradley C. Riemann, and Eric StorchSection 6: OCD-Related Disorders48. Obsessive-Compulsive and Related Disorders: A New Category in DSM-5 - Katharine A. Phillips49. Clinical Features, Assessment, and Treatment of body Dysmorphic Disorder - Lisa Zakhary, Hilary Weingarden, Alexandra Sullivan, and Sabine Wilhelm50. Body Dysmorphic Disorder: Neurobiology and Genetics - Jamie D. Feusner and Danyale McCurdy-McKinnon51. Trichtillomania and skin picking disorder - Jon E. Grant, Sarah A. Redden, Eric W. Leppink52. Hoarding Disorder: Clinical presentation and treatment - Randy O. Frost, Lucy Graves, Elizabeth Atkins53. Comorbidity in Pediatric OCD: Tourette Syndrom - Michael H. BlochSection 7. Comorbidity54. Mood and Anxiety Disorder Comorbidity in OCD - L. Baer, A. Fang, N.C. Berman, and W.E. Minichiello55. Psychological Trauma Exposure and Obsessive-Compulsive symptoms - Dean McKay and Rachel Ojserkis56. Eating Disorder Comorbidity with OCD - Marina Gershkovich, Olivia Pasucci, and Joanna Steinglass57. Obsessive-Compulsive Symptoms in Schizophrenia: Clinical features, neurobiological correlates and treatment - Michael Poyurovsky58. Differentiating Autism Spectrum disorder and OCD - Robert E. Accordino, W. Philip Bartel, Isobel W. Green, Christen L. Kidd, and Christopher J. McDougle59. Personality Pathology in OCD: Comorbidity and Contrast with OCPD and Other Personality Disorders - Michael G. Wheaton and Anthony PintoSection 8: Special Topics60. Etiological models of OCD: anxiety, obsession, compulsion, completeness - Christopher Pittenger, Patricia Gruner, Thomas A. Adams, Benjamin Kelmendi61. Evolutionary Perspectives of OCD - Gerrit I. van Schalkwyk and James F. Leckman62. Research Domain Criteria and OCD: An oxymoron? - Eyal Kalanthroff, Gideon E. Anholt, and Helen Blair Simpson63. OCD in Ethnoracial Minorities: Symptoms, barriers to care, and cultural considerations for treatment - Monnica T. Williams and Terence Ching64. OCD in the Educational Setting - Allen H. Weg65. The integration of new technological approaches in OCD care - Seth Feuerstein66. OCD, Advocacy, and Addressing Stigma - Jeff Szymanski, Carly Bourne67. Living with OCD - Elizabeth McIngvale

Christopher Pittenger is Director of the Yale OCD Research Clinic and Associate Professor of Psychiatry at Yale University. He trained at Columbia University, where he both received his medical degree and completed his Ph.D. with Nobel Prize winner Eric Kandel. He then completed his clinical training in psychiatry at Yale, where he joined the faculty in 2007. Dr. Pittenger lives outside New Haven, CT, with his wife, four children, three cats, and six chickens.

• 1. Introduction: Narratives of OCD - Elias Aboujaoude and Christopher PittengerSection 1: Clinical Presentation and Diagnosis2. Clinical Presentation of OCD - Fred Penzel3. Pediatric OCD: Clinical Course, Phenomology, and Assessment - Rachel E. Ginsberg, Samantha Morrison, and Anthony Puliafico4. Epidemiology, Comorbidity, and Burden of OCD - Albina R. Torres, Leonardo F. Fontenelle, Roseli G. Shavitt, Marcelo Q. Hoexter, Christopher Pittenger, and Euripedes C. Miguel5. Natural History and Long-Term Outcome of OCD - Michael H. Bloch6. Quality of Life and Psychosocial Functioning in OCD - Christina L. Boisseau, Carly M. Schwartzman, and Steven A. Rasmussen7. Psychodynamic perspectives on OCD - Robert A. KingSection 2: Phenomenology and Cognitive Psychology8. Symptom heterogeneity in OCD: A dimensional approach - Maria Concei Conceição do Rosário, Marcelo Batistutto, and Ygor Ferrao9. Incompleteness and harm avoidance - Stefano Pallanti, Jennifer Barnes, Christopher Pittenger, and Jane Eisen10. Disgust and OCD - Lauren Mancusi & Dean McKay11. Sensory Processing and Intolerance in OCD - Stephanie J. Grimaldi, and Emily R. Stern12. Scrupulosity and Slowness in OCD: Perfectionism as a Central Mechanism - Rachel Ojserkis and Dean McKay13. Variable Insight in OCD - Rebecca J. Hamblin, Jennifer Moonjung Park, Monica S. Wu, and Eric A. Storch14. Clinical Rating Scales for OCD - Joseph F. McGuire, Eric A. Storch, and Wayne Goodman15. Neuropsychosocial Function in OCD - Amitai Abramovitch16. Habits and Goals in OCD - Claire M. Gillan17. Intolerance of Uncertainty in Obsessive-Compulsive Disorder - Ryan J. Jacoby and Jonathan S. Abramowitz18. Pathological responsibility, thought-action fusion, and thought control in OCD - Christine PurdonSection 3: Biological Underpinnings19. Genetics Of OCD - Paul Arnold20. Neurocircuitry underlying OCD : neural networks underlying reward and action selection - Suzanne N. Haber21. A review and synthesis of functional neuroimaging studies of OCD - Brian P. Brennan and Scott L. Rauch22. Functional Imaging Studies of OCD: A Hypothesis-Driven Review - M.M. Vaghi and T.W. Robbins23. The Structure of the OCD Brain - Premika S.W. Boedhoe and Odile A. van den Heuvel24. Brain Functional Connectivity in OCD - Carles Soriano-Mas and Ben J. Harrison25. Neurotransmitter dysregulation in OCD - Ilse Graat, Martijn Figee, and Damiaan Denys26. Neuropeptides in OCD - Anahid Kabasakalian, Eric Hollander27. Influence of sex hormones on OCD - Valeria Guglielmi, Judith Souget, Wouter van Elzelingen, Ingo Willuhn, and Nienke Vulink28. PANDAS as a Post-Streptococcal Autoimmune Neuropsychiatric Form of OCD - Susan E. Swedo, Kyle A. WiliamsSection 4: Animal Studies29. Animal models of OCD: A conceptual framework - Christopher Pittenger, Stephanie Dulawa, and Summer L. Thompson30. Extinction of conditioned fear and avoidance: Relevance for OCD - Jose Rodriguez-Romaguera and Gregory J. Quirk31. OCD as a failure to integrate goal-directed and habitual action control - Laura Bradfield, Richard Morris, and Bernard W. Balleine32. Spontaneously Occurring Animal Models of OCD - Nicholas H. Dodman and Louis Shuster33. Mutant Mouse Models of OCD - Louis Y. Tee and Guoping Feng34. Targeted circuit manipulations in the modeling of OCD - Susanne E. Ahmari35. Pharmacological and behavioral rodent models of OCD - Summer L. Thompson and Stephanie C. DulawaSection 5: Treatment36. Overview of the treatment of OCD - H. Blair Simpson37. Exposure and Response Prevention in OCD - Jonathan S. Abramowitz38. Cognitive Therapy for OCD - Maureen Whittal39. Mindfulness and Acceptance Therapies for Obsessive-Compulsive and Related Disorders - Kate L. Morrison, Brooke M. Smith, and Michael P. Twohig40. Standard Evidence-Based Pharmacological Treatment for OCD - Jemma E. Reid, Samar Reghunandanan, Ann Roberts, and Naomi A. Fineberg41. The pharmacological treatment of refractory OCD - Christopher Pittenger42. Treatment of Pediatric OCD - S. Evelyn Stewart and Clare Bleakley43. Family accommodation in OCD: Prevalence, impact, and clinical implications - Kristin Koller and Eli R. Lebowitz44. Nutraceutical and alternative treatments for Obsessive compulsive and Related Disorders - David Camfield and Jerome Sarris45. Functional Neurosurgery in Severe and Treatment-Refractory OCD - Erica C. Keen, Alik S. Widge, and Darin D. Dougherty46. Deep Brain Stimulation for Intractable OCD - Wayne K. Goodman, Nigel Kennedy, Kyle Lapidus, and Brian H. Kopell47. Intensive Treatment Approaches for OCD - Joshua M. Nadeau, Bradley C. Riemann, and Eric StorchSection 6: OCD-Related Disorders48. Obsessive-Compulsive and Related Disorders: A New Category in DSM-5 - Katharine A. Phillips49. Clinical Features, Assessment, and Treatment of body Dysmorphic Disorder - Lisa Zakhary, Hilary Weingarden, Alexandra Sullivan, and Sabine Wilhelm50. Body Dysmorphic Disorder: Neurobiology and Genetics - Jamie D. Feusner and Danyale McCurdy-McKinnon51. Trichtillomania and skin picking disorder - Jon E. Grant, Sarah A. Redden, Eric W. Leppink52. Hoarding Disorder: Clinical presentation and treatment - Randy O. Frost, Lucy Graves, Elizabeth Atkins53. Comorbidity in Pediatric OCD: Tourette Syndrom - Michael H. BlochSection 7. Comorbidity54. Mood and Anxiety Disorder Comorbidity in OCD - L. Baer, A. Fang, N.C. Berman, and W.E. Minichiello55. Psychological Trauma Exposure and Obsessive-Compulsive symptoms - Dean McKay and Rachel Ojserkis56. Eating Disorder Comorbidity with OCD - Marina Gershkovich, Olivia Pasucci, and Joanna Steinglass57. Obsessive-Compulsive Symptoms in Schizophrenia: Clinical features, neurobiological correlates and treatment - Michael Poyurovsky58. Differentiating Autism Spectrum disorder and OCD - Robert E. Accordino, W. Philip Bartel, Isobel W. Green, Christen L. Kidd, and Christopher J. McDougle59. Personality Pathology in OCD: Comorbidity and Contrast with OCPD and Other Personality Disorders - Michael G. Wheaton and Anthony PintoSection 8: Special Topics60. Etiological models of OCD: anxiety, obsession, compulsion, completeness - Christopher Pittenger, Patricia Gruner, Thomas A. Adams, Benjamin Kelmendi61. Evolutionary Perspectives of OCD - Gerrit I. van Schalkwyk and James F. Leckman62. Research Domain Criteria and OCD: An oxymoron? - Eyal Kalanthroff, Gideon E. Anholt, and Helen Blair Simpson63. OCD in Ethnoracial Minorities: Symptoms, barriers to care, and cultural considerations for treatment - Monnica T. Williams and Terence Ching64. OCD in the Educational Setting - Allen H. Weg65. The integration of new technological approaches in OCD care - Seth Feuerstein66. OCD, Advocacy, and Addressing Stigma - Jeff Szymanski, Carly Bourne67. Living with OCD - Elizabeth McIngvale

Christopher Pittenger is Director of the Yale OCD Research Clinic and Associate Professor of Psychiatry at Yale University. He trained at Columbia University, where he both received his medical degree and completed his Ph.D. with Nobel Prize winner Eric Kandel. He then completed his clinical training in psychiatry at Yale, where he joined the faculty in 2007. Dr. Pittenger lives outside New Haven, CT, with his wife, four children, three cats, and six chickens.

• 1. Introduction: Narratives of OCD - Elias Aboujaoude and Christopher PittengerSection 1: Clinical Presentation and Diagnosis2. Clinical Presentation of OCD - Fred Penzel3. Pediatric OCD: Clinical Course, Phenomology, and Assessment - Rachel E. Ginsberg, Samantha Morrison, and Anthony Puliafico4. Epidemiology, Comorbidity, and Burden of OCD - Albina R. Torres, Leonardo F. Fontenelle, Roseli G. Shavitt, Marcelo Q. Hoexter, Christopher Pittenger, and Euripedes C. Miguel5. Natural History and Long-Term Outcome of OCD - Michael H. Bloch6. Quality of Life and Psychosocial Functioning in OCD - Christina L. Boisseau, Carly M. Schwartzman, and Steven A. Rasmussen7. Psychodynamic perspectives on OCD - Robert A. KingSection 2: Phenomenology and Cognitive Psychology8. Symptom heterogeneity in OCD: A dimensional approach - Maria Concei Conceição do Rosário, Marcelo Batistutto, and Ygor Ferrao9. Incompleteness and harm avoidance - Stefano Pallanti, Jennifer Barnes, Christopher Pittenger, and Jane Eisen10. Disgust and OCD - Lauren Mancusi & Dean McKay11. Sensory Processing and Intolerance in OCD - Stephanie J. Grimaldi, and Emily R. Stern12. Scrupulosity and Slowness in OCD: Perfectionism as a Central Mechanism - Rachel Ojserkis and Dean McKay13. Variable Insight in OCD - Rebecca J. Hamblin, Jennifer Moonjung Park, Monica S. Wu, and Eric A. Storch14. Clinical Rating Scales for OCD - Joseph F. McGuire, Eric A. Storch, and Wayne Goodman15. Neuropsychosocial Function in OCD - Amitai Abramovitch16. Habits and Goals in OCD - Claire M. Gillan17. Intolerance of Uncertainty in Obsessive-Compulsive Disorder - Ryan J. Jacoby and Jonathan S. Abramowitz18. Pathological responsibility, thought-action fusion, and thought control in OCD - Christine PurdonSection 3: Biological Underpinnings19. Genetics Of OCD - Paul Arnold20. Neurocircuitry underlying OCD : neural networks underlying reward and action selection - Suzanne N. Haber21. A review and synthesis of functional neuroimaging studies of OCD - Brian P. Brennan and Scott L. Rauch22. Functional Imaging Studies of OCD: A Hypothesis-Driven Review - M.M. Vaghi and T.W. Robbins23. The Structure of the OCD Brain - Premika S.W. Boedhoe and Odile A. van den Heuvel24. Brain Functional Connectivity in OCD - Carles Soriano-Mas and Ben J. Harrison25. Neurotransmitter dysregulation in OCD - Ilse Graat, Martijn Figee, and Damiaan Denys26. Neuropeptides in OCD - Anahid Kabasakalian, Eric Hollander27. Influence of sex hormones on OCD - Valeria Guglielmi, Judith Souget, Wouter van Elzelingen, Ingo Willuhn, and Nienke Vulink28. PANDAS as a Post-Streptococcal Autoimmune Neuropsychiatric Form of OCD - Susan E. Swedo, Kyle A. WiliamsSection 4: Animal Studies29. Animal models of OCD: A conceptual framework - Christopher Pittenger, Stephanie Dulawa, and Summer L. Thompson30. Extinction of conditioned fear and avoidance: Relevance for OCD - Jose Rodriguez-Romaguera and Gregory J. Quirk31. OCD as a failure to integrate goal-directed and habitual action control - Laura Bradfield, Richard Morris, and Bernard W. Balleine32. Spontaneously Occurring Animal Models of OCD - Nicholas H. Dodman and Louis Shuster33. Mutant Mouse Models of OCD - Louis Y. Tee and Guoping Feng34. Targeted circuit manipulations in the modeling of OCD - Susanne E. Ahmari35. Pharmacological and behavioral rodent models of OCD - Summer L. Thompson and Stephanie C. DulawaSection 5: Treatment36. Overview of the treatment of OCD - H. Blair Simpson37. Exposure and Response Prevention in OCD - Jonathan S. Abramowitz38. Cognitive Therapy for OCD - Maureen Whittal39. Mindfulness and Acceptance Therapies for Obsessive-Compulsive and Related Disorders - Kate L. Morrison, Brooke M. Smith, and Michael P. Twohig40. Standard Evidence-Based Pharmacological Treatment for OCD - Jemma E. Reid, Samar Reghunandanan, Ann Roberts, and Naomi A. Fineberg41. The pharmacological treatment of refractory OCD - Christopher Pittenger42. Treatment of Pediatric OCD - S. Evelyn Stewart and Clare Bleakley43. Family accommodation in OCD: Prevalence, impact, and clinical implications - Kristin Koller and Eli R. Lebowitz44. Nutraceutical and alternative treatments for Obsessive compulsive and Related Disorders - David Camfield and Jerome Sarris45. Functional Neurosurgery in Severe and Treatment-Refractory OCD - Erica C. Keen, Alik S. Widge, and Darin D. Dougherty46. Deep Brain Stimulation for Intractable OCD - Wayne K. Goodman, Nigel Kennedy, Kyle Lapidus, and Brian H. Kopell47. Intensive Treatment Approaches for OCD - Joshua M. Nadeau, Bradley C. Riemann, and Eric StorchSection 6: OCD-Related Disorders48. Obsessive-Compulsive and Related Disorders: A New Category in DSM-5 - Katharine A. Phillips49. Clinical Features, Assessment, and Treatment of body Dysmorphic Disorder - Lisa Zakhary, Hilary Weingarden, Alexandra Sullivan, and Sabine Wilhelm50. Body Dysmorphic Disorder: Neurobiology and Genetics - Jamie D. Feusner and Danyale McCurdy-McKinnon51. Trichtillomania and skin picking disorder - Jon E. Grant, Sarah A. Redden, Eric W. Leppink52. Hoarding Disorder: Clinical presentation and treatment - Randy O. Frost, Lucy Graves, Elizabeth Atkins53. Comorbidity in Pediatric OCD: Tourette Syndrom - Michael H. BlochSection 7. Comorbidity54. Mood and Anxiety Disorder Comorbidity in OCD - L. Baer, A. Fang, N.C. Berman, and W.E. Minichiello55. Psychological Trauma Exposure and Obsessive-Compulsive symptoms - Dean McKay and Rachel Ojserkis56. Eating Disorder Comorbidity with OCD - Marina Gershkovich, Olivia Pasucci, and Joanna Steinglass57. Obsessive-Compulsive Symptoms in Schizophrenia: Clinical features, neurobiological correlates and treatment - Michael Poyurovsky58. Differentiating Autism Spectrum disorder and OCD - Robert E. Accordino, W. Philip Bartel, Isobel W. Green, Christen L. Kidd, and Christopher J. McDougle59. Personality Pathology in OCD: Comorbidity and Contrast with OCPD and Other Personality Disorders - Michael G. Wheaton and Anthony PintoSection 8: Special Topics60. Etiological models of OCD: anxiety, obsession, compulsion, completeness - Christopher Pittenger, Patricia Gruner, Thomas A. Adams, Benjamin Kelmendi61. Evolutionary Perspectives of OCD - Gerrit I. van Schalkwyk and James F. Leckman62. Research Domain Criteria and OCD: An oxymoron? - Eyal Kalanthroff, Gideon E. Anholt, and Helen Blair Simpson63. OCD in Ethnoracial Minorities: Symptoms, barriers to care, and cultural considerations for treatment - Monnica T. Williams and Terence Ching64. OCD in the Educational Setting - Allen H. Weg65. The integration of new technological approaches in OCD care - Seth Feuerstein66. OCD, Advocacy, and Addressing Stigma - Jeff Szymanski, Carly Bourne67. Living with OCD - Elizabeth McIngvale