In this issue of Otolaryngologic Clinics, guest editors Drs. Nausheen Jamal and Todd Falcone bring their considerable expertise to the topic of Obesity, Weight Loss, and Otolaryngology Implications. Top experts explore how obesity intersects with every major subspecialty in ENT, examining perioperative risk assessment, sleep medicine and sleep surgery, and advances in laryngology, airway surgery, rhinology and allergy, and much more. This issue also highlights critical considerations in bariatric surgery and the upper aerodigestive tract, alongside practical guidance on lifestyle medicine and complementary, integrative, and functional approaches for the obese patient.