Nutritional and Therapeutic Interventions for Diabetes and Metabolic Syndrome

Debasis Bagchi, PhD, MACN, CNS, MAIChE, received his Ph.D. in Medicinal Chemistry in 1982. He is a Professor in the Department of Pharmacological and Pharmaceutical Sciences at the University of Houston College of Pharmacy, Houston, TX, and Chief Scientific Officer at Cepham Research Center, Piscataway, NJ, Adjunct Faculty in Texas Southern University, Houston, TX. He served as the Senior Vice President of Research & Development of InterHealth Nutraceuticals Inc, Benicia, CA, from 1998 until Feb 2011, and then as Director of Innovation and Clinical Affairs, of Iovate Health Sciences, Oakville, ON, until June 2013. Dr. Bagchi received the Master of American College of Nutrition Award in October 2010. He is the Past Chairman of International Society of Nutraceuticals and Functional Foods (ISNFF), Past President of American College of Nutrition, Clearwater, FL, and Past Chair of the Nutraceuticals and Functional Foods Division of Institute of Food Technologists (IFT), Chicago, IL. He is serving as a Distinguished Advisor on the Japanese Institute for Health Food Standards (JIHFS), Tokyo, Japan. Dr. Bagchi is a Member of the Study Section and Peer Review Committee of the National Institutes of Health (NIH), Bethesda, MD. He has published 321 papers in peer reviewed journals, 30 books, and 18 patents. Dr. Bagchi is also a Member of the Society of Toxicology, Member of the New York Academy of Sciences, Fellow of the Nutrition Research Academy, and Member of the TCE stakeholder Committee of the Wright Patterson Air Force Base, OH. He is also Associate Editor for the Journal of Functional Foods, Journal of the American College of Nutrition, and the Archives of Medical and Biomedical Research, and is also serving as Editorial Board Member of numerous peer reviewed journals, including Antioxidants & Redox Signaling, Cancer Letters, Toxicology Mechanisms and Methods, and The Original Internist, among others. Dr. Sreejayan Nair is a Professor of Pharmacology and the Associate Dean for Research in the School of Pharmacy, College of Health Sciences, University of Wyoming. He also serves as the Director of the interdisciplinary Biomedical Sciences Graduate Program in the University of Wyoming. Dr. Nair earned his bachelors, masters and PhD degree in Pharmaceutical Sciences from the College of Pharmaceutical Sciences, Manipal, India. He received his post-doctoral trainings at the Department of Medicine-II, Ludwig Maximillians University, Klinikum Grosshadern, Munich, Germany, and at the Department of Physiology, University of Tennessee Health Sciences Center, Memphis, TN. His research interests are diabetes and cardiovascular disease. He has published over 75 research papers in peer-reviewed journals and presented at various national and international conferences. His research has been funded by the American Heart Association, American Diabetes Association, and the National Institutes of Health. He has co-edited three books related to diabetes and cardiovascular disease. He is a Fellow of the American College of Nutrition.

• I. EPIDEMIOLOGY AND OVERVIEW1. Type 1 Diabetes Mellitus: An OverviewSALEH ADI AND ANDREA GERARD GONZALEZ2. Prediabetes: Prevalence, Pathogenesis, and Recognition of Enhanced RiskALOK K. GUPTA, AJAY MENON, MEGHAN BRASHEAR AND WILLIAM D. JOHNSON3. Targeting Prediabetes to Preempt DiabetesSREEDHARAN N, MAHADEV RAO AND SONAL SEKHAR M4. Obesity and Type 2 Diabetes in Youths: New Challenges to OvercomeNICOLA SANTORO, COSIMO GIANNINI AND SONIA CAPRIO5. Roles of Environmental Pollution and Pesticides in Diabetes and Obesity: The Epidemiological EvidenceCHARLES J. EVERETT, DANIRA MEDUNJANIN AND IVAR L. FRITHSEN6. An Overview of the Roles of the Gut Microbiome in Obesity and DiabetesGILLIAN M. BARLOW, EUGENIA A. LIN AND RUCHI MATHURII. TYPES OF DIABETES AND ITS CORRELATION WITH OTHER DISEASES7. Role of Peripheral Neuropathy in the Development of Foot Ulceration and Impaired Wound Healing in Diabetes MellitusFRANCESCO TECILAZICH AND ARISTIDIS VEVES8. The Association of Diabetes in the Onset of Dementia in the Elderly Population: An OverviewABHAI KUMAR AND SMITA SINGH9. The Role of Insulin Resistance in the Cardiorenal SyndromeADAM WHALEY-CONNELL AND JAMES R. SOWERS10. An Overview on Diabetic NephropathyKEI FUKAMI AND SHO-ICHI YAMAGISHI11. An Overview of Diabetic RetinopathySHINTARO NAKAO, SHIGEO YOSHIDA AND KOH-HEI SONODA12. An Overview of Gestational DiabetesCHRISTOPHER FEDERICO AND GABRIELLA PRIDJIAN13. Diabetes, a Potential Threat to the Development and Progression of Tumor Cells in IndividualsSAYANTAN MAITRA, STABAK DAS AND PRADIPTA BANERJEEIII. MOLECULAR INSIGHTS OF DIABETES AND METABOLIC SYNDROME14. Lipid-Induced Insulin Resistance: Molecular Mechanisms and Clinical ImplicationsSATINATH MUKHOPADHYAY, DEEP DUTTA AND DIPYAMAN GANGULY15. Gene–Environment Interaction in the Pathogenesis of Type 2 DiabetesKIAN-PENG GOH16. Renal Sodium-Glucose Transporter-2 Inhibitors and Antidiabetic AgentsANAND S. NAIR, DEBASIS BAGCHI AND SREEJAYAN NAIR17. Emerging Role of MicroRNA in Diabetes MellitusANAND S. NAIR AND DEBASIS BAGCHIIV. PATHOPHYSIOLOGY18. Insulin Resistance Syndrome: A Crucial Example Where a Physiological Continuum of Risks Needs AttentionHARRY G. PREUSS19. Sleep Disturbances, Hypertension, and Type 2 DiabetesMICHELLE A. MILLER AND FRANCESCO P. CAPPUCCIO20. Roles of Pancreatic Cell Function, Liver, Skeletal Muscle, and Adipose Tissue in Diabetes and the Metabolic SyndromeBEVERLY S. MÜHLHÄUSLER21. Glycemic Variability and Its Clinical ImplicationsNARSINGH VERMA22. Diabetic Wound InflammationSCOTT CHAFFEE, AMITAVA DAS, SUMAN SANTRA AND SASHWATI ROY23. Sarcopenia, Diabetes, and Nutritional InterventionSHEILA M. WICKS, IVAN SALAMON, ANGELA I. CALDERON, ESPERANZA CARCACHE DE BLANCO AND GAIL B. MAHADYV. PREVENTION AND TREATMENT 1: DIET, EXERCISE, SUPPLEMENTS AND ALTERNATIVE MEDICINES24. Dietary Polyphenols, Gut Microbiota, and Intestinal Epithelial HealthMEIJUN ZHU25. Reducing the Risk of Diabetes and Metabolic Syndrome With Exercise and Physical ActivityDAWN BLATT AND CHERI L. GOSTIC26. Nutraceutical Impact on the Pathophysiology of Diabetes MellitusODETE MENDES, LEE KOETZNER AND JAYSON CHEN27. Therapeutic Effect of Fucoxanthin on Metabolic Syndrome and Type 2 DiabetesKAZUO MIYASHITA, SHOW NISHIKAWA AND MASASHI HOSOKAWA28. Safety and Antidiabetic Efficacy of a Novel Trigonella foenum-graecum Seed ExtractANAND SWAROOP, MANASHI BAGCHI, HARRY G. PREUSS AND DEBASIS BAGCHI29. Beneficial Effects of Chromium(III) and Vanadium Supplements in DiabetesJOHN B. VINCENT30. Protective Role of Alpha-Tocopherol in Diabetic NephropathyDAIKI HAYASHI AND YASUHITO SHIRAI31. Antidiabetic Activity of Curcumin: Insight Into Its Mechanisms of ActionMARZENA WOJCIK, MICHAL KRAWCZYK AND LUCYNA A. WOZNIAK32. Meal Plans for Diabetics: Caloric Intake, Calorie Counting, and Glycemic IndexPAULIN MOSZCZYŃSKI AND ZBIGNIEW TABAROWSKIVI. PREVENTION AND TREATMENT 2: DRUGS AND PHARMACEUTICALS33. The Evolution of Glucose-Lowering Drugs for Type 2 DiabetesANDREW J. KRENTZ AND ALAN J. SINCLAIR34. Current Antidiabetic Drugs: Review of Their Efficacy and SafetyMD. AKIL HOSSAIN AND ROKEYA PERVIN35. HDACs in Diabetes: A New Era of Epigenetic DrugLUÍS F. SCHÜTZ, MIN HI PARK AND MAHUA CHOUDHURYVII. NOVEL INNOVATIONS36. Noninvasive Blood Glucose MeasurementYASUHIRO UWADAIRA AND AKIFUMI IKEHATAVIII. DIABETES IN ANIMALS AND TREATMENT37. Diabetes Mellitus in Animals: Diagnosis and Treatment of Diabetes Mellitus in Dogs and CatsDEBORAH S. GRECO