Nucleic Acid Therapeutics in Cancer

Inbunden, Engelska, 2004

1 429 kr

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discusses the development of simple, reliable tools for modifying gene expression "on demand"; addresses the numerous problems slowing down progress in this field, such as the variable and unreliable use of OLGs to modify gene expression; addresses the poor understanding of the processes which regulate trafficking and govern whether and where an oligonucleotide (OLG) can interact with its target.

Produktinformation

Utgivningsdatum2004-03-25
Mått178 x 254 x undefined mm
FormatInbunden
SpråkEngelska
SerieCancer Drug Discovery and Development
Antal sidor221
FörlagHumana Press Inc.
ISBN9781588292582

Tillhör följande kategorier

Onkologi inom Medicin

I. Introduction and Perspective.- 1 Antisense Methodology: An Assessment After 25 Years.- 2 Nucleic Acid Therapeutics: An Introduction.- II. Basic Methodology.- 3 Targeted Genome Modification Via Triple Helix Formation.- 4 Therapeutic Applications of Ribozymes.- 5 Use of Catalytic DNA in Target Validation and Therapeutics.- 6 Targeted Destruction of Small, Stable RNAs: Principles Applicable to Antisense Therapies.- 7 Mechanism of Action of Antisense RNA in Eukaryotic Cells.- III. Delivery.- 8 The Transport of Oligonucleotides Into Cells.- 9 Peptide-Mediated Delivery of Antisense Oligonucleotides and Related Material.- 10 Molecular Vectors for Gene Delivery to Cancer Cells.- IV. Targeting.- 11 Considerations on the Design of Antisense Oligonucleotides.- 12 Identification of Hybridization Accessible Sequence in Messenger RNA.- V. Clinical Targets.- 13 Nucleic Acids As Gene Targeting Therapeutics.- 14 LY900003 (Isis 3521) and G3139 (Genasense; Oblimersen): Phosphorothioate Antisense Oligonucleotides With Pleiotropic Mechanisms of Action.- 15 Antisense Protein Kinase A-RI? Restores Normal Signal Transduction Signatures to Inhibit Tumor Growth.