Nucleic Acid-Based Nanomaterials

Stabilities and Applications

Inbunden, Engelska, 2024

AvYunfeng Lin,Yunfeng Lin,Shaojingya Gao,China) Lin, Yunfeng (Sichuan University,China) Gao, Shaojingya (Sichuan University

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Learn about the cutting-edge nanotechnologies that play an important role in clinical and medical therapies Nucleic acids, the biomolecules that carry most of nature’s critical genetic information, are an omnipresent component of life on earth. Nanomaterials incorporating or otherwise built around nucleic acids and their key properties have a number of clinical and medical applications, including drug delivery and more. Biomaterials scientists and other professionals in these fields can benefit enormously from increased knowledge of these invaluable materials. Nucleic Acid-Based Nanomaterials supplies a thorough, rigorous overview of these materials and their possible applications. Beginning with an introduction to the history of nanomaterials and their nucleic acid-based subcategories, the book offers a detailed and state-of-the-art survey of the current research into these molecules, efforts to increase their biostability, and their incorporation into a range of industries. The result is an essential contribution to materials science in a variety of life-saving contexts. Nucleic Acid-Based Nanomaterials readers will also find: Application-oriented structure that grounds general concepts in their specific instantiationsDetailed discussion of applications including drug delivery, tissue engineering, antimicrobial therapy, and moreA rigorous yet accessible approach suitable for both academia and industryNucleic Acid-Based Nanomaterials is ideal for chemists of all types, particularly biochemists and medical chemists, and those in industry.

Produktinformation

Utgivningsdatum2024-06-12
Mått170 x 244 x 15 mm
Vikt680 g
FormatInbunden
SpråkEngelska
Antal sidor224
FörlagWiley-VCH Verlag GmbH
ISBN9783527352050

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Teknik: allmänt inom Naturvetenskap och teknik

Yunfeng Lin, PhD, is a full professor at Sichuan University, China. He also obtained his PhD from Sichuan University in 2006. He is Vice-Director of West China Medical Center, Sichuan University, and Vice-Director of State Key Laboratory of Oral Diseases.Shaojingya Gao, PhD, MSc, is a postdoctoral researcher in State Key Laboratory of Oral Diseases. She earned her MSc in 2019 and her PhD in 2022 from West China College of Stomatology in Sichuan University, China.

Preface xi1 Introductions of Nucleic Acid-Based Nanomaterials 1Shaojingya Gao and Yunfeng Lin1.1 History of DNA-Based Nanomaterials - Design and Construction 32 The Methods to Improve the Stability of Nucleic Acid-Based Nanomaterials 15Xueping Xie2.1 Introduction 152.2 Methods to Improve Stability 162.3 Conclusion and Recommendations 263 Framework Nucleic Acid-Based Nanomaterials: A Promising Vehicle for Small Molecular Cargos 37Yanjing Li3.1 Basis of FNAs as Potential Drug Carriers 383.2 Small-molecule Cargos 413.3 Merits of FNA Delivery Systems in Biomedical Application 463.4 Conclusions and Prospects 524 The Application of Framework Nucleic Acid-Based Nanomaterials in the Treatment of Mitochondrial Dysfunction 61Lan Yao and Tao Zhang4.1 Introduction 614.2 Treatment Mechanisms in Mitochondrial Dysfunction 614.3 Nucleic Acid Nanomaterial-Based Delivery System in Mitochondrial Treatment 654.4 Challenges and Prospectives 715 Regeneration of Bone-Related Diseases by Nucleic Acid-Based Nanomaterials: Perspectives from Tissue Regeneration and Molecular Medicine 81Xiaoru Shao5.1 Introduction 815.2 The Development Process of Functional Nucleic Acid 825.3 Nucleic Acid-Based Functional Nanomaterials 845.4 Multiple Roles of Nucleic Acid-Based Functional Nanomaterials in Bone Tissue Repair and Regeneration 895.5 Conclusion and Perspectives 946 In Situ Fluorescence Imaging and Biotherapy of Tumor Based on Hybridization Chain Reaction 101Ye Chen, Songhang Li, and Taoran Tian6.1 Hybridization Chain Reaction 1026.2 Nucleic Acid Detection 1026.3 Protein Detection 1076.4 Multiple Target Detection 1096.5 HCR-Based Assembly Nanoplatforms 1136.6 HCR-Based Tumor Biotherapy 1156.7 Conclusion 1167 Application and Prospects of Framework Nucleic Acid-Based Nanomaterials in Tumor Therapy 123Tianyu Chen and Xiaoxiao Cai7.1 Development of Nucleic Acid Nanomaterials 1247.2 Properties and Applications of Nucleic Acid Nanomaterials 1257.3 Conclusion 1338 Application of Framework Nucleic Acid-Based Nanomaterials in the Treatment of Endocrine and Metabolic Diseases 139Jingang Xiao8.1 Endocrine and Metabolic Diseases 1398.2 Nucleic Acid Nanomaterials 1418.3 Nucleic Acid and Drugs 1418.4 Nucleic Acid Nanomaterials for Endocrine and Metabolic Diseases 1448.5 Conclusion and Outlook 1499 The Antibacterial Applications of Framework Nucleic Acid-Based Nanomaterials: Current Progress and Further Perspectives 161Zhiqiang Liu and Yue Sun9.1 Some Advantages of DNA Nanostructures in the Antibacterial Field 1639.2 Application of 2D Nanostructures in the Antibacterial Field 1649.3 Application of 3D DNA Nanostructures in the Antibacterial Field 1669.4 Application of DNA Hydrogel Nanostructures in the Antibacterial Field 1709.5 Challenges and Further Perspectives 17210 Framework Nucleic Acid Nanomaterial-Based Therapy for Osteoarthritis: Progress and Prospects 181Yangxue Yao, Hongxiao Huang, and Sirong Shi10.1 Introduction 18110.2 Pathology of OA 18110.3 Risk Factors of OA 18310.4 Challenges for OA Therapy 18310.5 Nucleic Acid Nanomaterial-Based Therapy for OA 18410.6 Conclusion and Prospects 194References 195Index 205