Nuclear Receptors: From Structure to the Clinic

• 1. Twenty-five Years of Nuclear Receptor Structure Analysis: From the Laboratory to the Clinic.- Part A. ALLOSTERIC REGULATION AND NUCLEAR RECEPTOR COMPLEX DYNAMICS. -2. Corticosteroid Receptors.- 3. Glucocorticoid Receptor Structure and Function.- 4. What Determines the Difference in DNA Binding Between the Androgen and the Glucocorticoid Receptors?.- 5. Allosteric Regulation and Intrinsic Disorder in Nuclear Hormone Receptors.- 6. Structural Analyses of Ordered and Disordered Regions in Ecdysteroid Receptor.- 7. Structural Analysis of Heterodimeric Nuclear Receptors.- Part B. NUCLEAR RECEPTOR CO-REGULATORY PROTEIN INTERACTIONS.- 8. Primate-specific Multi-functional Androgen Receptor Coregulator and Proto-oncogene Melanoma Antigen-A11 (MAGE-A11).- 9. Assembly and Regulation of Nuclear Receptor Corepressor Complexes.- Part C. TAKING NUCLEAR RECEPTOR STRUCTURE INTO THE CLINIC.- 10. Thinking Outside the Box: Alternative Binding Sites in the Ligand Binding Domain of Nuclear Receptors.-11. Selective Estrogen Receptor Modulators (SERMs) and Selective Androgen Receptor Modulators (SARMs).

“Given the rapid advances in the field of nuclearreceptor research, especially their role in cell proliferation, metabolism, andhomeostasis, which make them prime targets for a wide range of diseases such ascancer and metabolic diseases, this book does an excellent job of coveringtheir structure and function and translational opportunities for drugdiscovery. … The book targets students, scientists, and other clinicians suchas oncologists and endocrinologists interested in the field of nuclearreceptors.” (Omer Iqbal, Doody’s Book Reviews, October, 2015)