Del i serien Molecular Biology Intelligence Unit

Nuclear Envelope Dynamics in Embryos and Somatic Cells

Häftad, Engelska, 2012

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This volume provides an exhaustive review of the most current knowledge of the composition, architecture and dynamics of the nuclear envelope.

Produktinformation

Utgivningsdatum2012-11-01
Mått155 x 235 x 11 mm
Vikt300 g
FormatHäftad
SpråkEngelska
SerieMolecular Biology Intelligence Unit
Antal sidor174
FörlagSpringer-Verlag New York Inc.
ISBN9781461349372

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1. Dynamics of the Vertebrate Nuclear Envelope.- Abstract.- Interphase Nuclear Envelope Structure.- Nuclear Envelope Disassembly.- Nuclear Assembly.- Concluding Remarks.- 2. Dynamics of Nuclear Envelope Proteins During the Cell Cycle in Mammalian Cells.- Abstract.- Why Should Nuclear Envelope Proteins Be Dynamic?.- What is the Nuclear Envelope Made of?.- Studying Nuclear Envelope Protein Dynamics.- Dynamics in Interphase.- Chromosomes Do not Move Much in Interphase.- Dynamics in Mitosis.- INM Proteins: Switching Retention Off and Back On.- Lamina: Tearing of a Polymer, Dispersion and Re-Import of Monomers.- Pore Complex Disassembly and Assembly: Many Open Questions.- Chromosomes: A Complex Template for Nuclear Assembly.- Concluding Remarks.- 3. Targeting and Retention of Proteins in the Inner and Pore Membranes of the Nuclear Envelope.- Abstract.- Targeting of Integral Membrane Proteins to the Inner Nuclear Membrane.- Targeting and Retention of Integral Membrane Proteins to the Pore Membrane.- Targeting of Peripheral Membrane Proteins to the Inner Nuclear Membrane.- Conclusion.- 4. Dynamic Connections of Nuclear Envelope Proteins to Chromatin and the Nuclear Matrix.- Abstract.- Major Components of the Peripheral Nuclear Lamina.- Lamina Proteins in the Nuclear Interior.- Interactions at the Interface Between the Lamina and the Nuclear Scaffold/Chromatin.- Potential Functions of Lamina Proteins in Interphase.- Dynamics and Functions of Lamina-Chromatin Interactions During Mitosis.- Conclusions and Future Prospects.- 5. Role of Ran GTPase in Nuclear Envelope Assembly.- Abstract.- Background.- Control of Nuclear Envelope Assembly by Ran.- 6. Mitotic Control of Nuclear Pore Complex Assembly.- The Nuclear Lamina.- The Inner Nuclear Membrane.- Nuclear Pore Complexes.- Dynamicsof the Nuclear Envelope During Mitosis.- Nuclear Envelope Breakdown.- Nuclear Envelope Reformation.- NPC Assembly.- When Does the NPC Become Functional?.- Summary.- 7. Structure, Function and Biogenesis of the Nuclear Envelope in the Yeast Saccharomyces cerevisiae.- Overview of the Yeast NPC and its Function in Transport.- Composition and Structure-Function Relationships of the Yeast NPC.- Biogenesis of the Yeast NPCs and Their Role in the Organization of the NE.- Integral Membrane Proteins of the Yeast NE and Their Function.- 8. Nuclear Envelope Breakdown and Reassembly in C. elegans: Evolutionary Aspects of Lamina Structure and Function.- Abstract.- The Structure and Protein Composition of the Nuclear Lamina in C. elegans.- Possible Functions of the Nuclear Lamina in G elegans.- Nuclear Dynamics in G elegans During Mitosis.- 9. Nuclear Envelope Assembly in Gametes and Pronuclei.- Abstract.- Background.- Sperm Nuclear Envelope Disassembly.- Membrane Vesicle Fractions Contributing to the Nuclear Envelope.- Binding of Egg Cytoplasmic Vesicles to Sperm Chromatin and Nuclear Envelope Remnants.- Fusion of Nuclear Envelope Precursor Vesicles.- Completion of Male Pronuclear Envelope Formation.- Comparison with Other Systems and Speculations.- Issues for Future Investigation.- 10. Nuclear Envelope Dynamics in Drosophila Pronuclear Formation and in Embryos.- Drosophila Nuclear Envelopes.- Developmental Changes in Nuclear Envelopes Around the Time of Fertilization.- Conclusion.- 11. The Distribution of Emerin and Lamins in X-Linked Emery-Dreifuss Muscular Dystrophy.- A Brief History of EDMD.- The Normal Distribution of Emerin and Lamins.- Distribution of Emerin and Lamins in X-Linked EDMD.- 12. Laminopathies: One Gene, Two Proteins, Five Diseases.- Abstract.- Disorders of Cardiac and/or Skeletal Muscles Linked to LMNA Alterations.- Lipodystrophies and the Familial Partial Lipodystrophy of the Dunnigan Type (FPLD).- Familial Partial Lipodystrophy of the Dunnigan Type (FPLD).- Could Some Patients with LMNA Mutations be Affected by Both Skeletal or Cardiac Muscular Symptoms and Lipodystrophy?.- Experimental Models of Lamin A/C Alterations.- Nuclear Alterations in Cells Harboring LMNA Mutations.- Conclusion.- Addendum.