Novel Drug Delivery Systems for Phytoconstituents

EditorsMadhu Gupta has research experience pertaining to drug deliveryto nanoformulations for magical molecule delivery, bioligands fortargeting of bioactives and drug moiety, biopolymers, cancer nanomedicine,as well as topical delivery that is carried out at theDepartment of Pharmaceutical Sciences, Dr. H.S. Gour CentralUniversity, Sagar. Dr. Gupta has done her B. Pharm (Gold Medalist),M. Pharm, PhD in Pharmaceutics with experience of more than12 years in academics, administrative functions, and research inareas of pharmaceutical nanotechnology and targeted drug deliveryrelated to cancer, fungal infection, and psoriasis.Presently she is working as an officer on special duty to Vice-Chancellor in Delhi Pharmaceutical Sciences and ResearchUniversity. Along with teaching and research, she is Chief OperatingOfficer of World Class Skill Centre courses, PRO, website In-charge,IQAC in addition to much other managerial work.She is pioneer scientist in the fields of nanotechnology and drug delivery. She has judiciously exploitedbioligands for targeting of bioactives and drug moiety. She has over 40 research publications to hercredit published in journals of high scientific impact and contributed 18 chapters in various renownedbooks and to several international and national books. Dr. Gupta has H-index of 12, i10-index of 14, andmore than 600 citations. She has been awarded by various national and international conferences in theform of best oral and poster presentation award and other national and international awards. She hassupervised 15 MPharm students. Dr. Gupta has availed several prestigious fellowships and awardsSRF AICTE (NDF), JRF (AICTE), Travel grant awards (DST, ICMR, INSA, and DBT, MPCST), Prof.G.P. Nair Award (2004), and Prof. C.S. Chauhan Award (2004). She has her research work at BioAsiaInnovation Award—2012, Grace India Awards, Youth Education Award 2018, and Young ResearcherAward. She has successfully completed one project that is funded by MPCST Bhopal.She is the nominee of CPCSEA and also an active member of various pharmaceutical bodies suchas APTI and others. She is a reviewer of various journals of repute. She has attended various conferences/seminars/workshops/FDPs as organizer/coordinator/resource person/participant. Dr. Gupta andher team have been selected for funding of one start-up.Durgesh Nandini Chauhan completed her BPharm degree inPharmacy from the Rajiv Gandhi Proudyogiki Vishwavidyalaya,Bhopal, India, and her MPharma (pharmaceutical sciences) in pharmaceuticsfrom Uttar Pradesh Technical University, currently Dr. A.P.J.Abdul Kalam Technical University, Lucknow, in 2006. Mrs. DurgeshNandini Chauhan has 10 years of academic (teaching) experience fromInstitutes of India in pharmaceutical sciences. She taught such subjectsas pharmaceutics, pharmacognosy, traditional concepts of medicinalplants, drug-delivery phytochemistry, cosmetic technology, pharmaceuticalengineering, pharmaceutical packaging, quality assurance,dosage form designing, and anatomy and physiology.She is member of the Association of Pharmaceutical Teachersof India, SILAE: Società Italo-Latinoamericana di Etnomedicina(The Scientific Network on Ethnomedicine, Italy), and so forth. Herprevious research work includes Penetration Enhancement Studies on Organogel of OxytetracyclineHCL. She also attended AICTE-sponsored Staff Development Program on “Effects of Teaching andLearning Skills in Pharmacy-Tool for Improvement of Young Pharmacy Teachers” and workshop onAnalytical Instruments. She has written more than 10 publications in national and international journals,13 book chapters, and authored 2 books: Optimization and Evaluation of an Organogel and Plant andMarine Based Phytochemicals for Human Health: Attributes, Potential, and Use. She is also activeas a reviewer for several international scientific journals and active participant in national and internationalconferences such as Bhartiya Vigyan Sammelan and International Convention of Society ofPharmacognosy. Presently she is part of the Ishita Research Organization, Raipur, India, as a freelancewriter and guiding pharmacy, Ayurvedic, and science students in their research projects.Vikas Sharma is Associate Professor and Principal Shri RawatpuraSarkar Institute of Pharmacy Datia, India. Dr. Sharma obtained hisBPharm from Jiwaji University Gwalior, MPharm in Pharmacognosy,and PhD from Dr. H.S. Gour Central University Sagar, India.Dr. Sharma has more than 12 years of teaching and research experience.He has made significant contributions in the area of medicinalplant research. He has been working on evidence-based validation ofmedicinal plants and pharmacological screening of herbal drugs. Dr.Sharma works on marker and biomarker analysis of herbs for qualityevaluation. He has also made significant contributions to developmentof chemical profiling of extracts and formulation through TLC,HPTLC, and LC-MS. He is supervising scientific research of the postgraduationand the doctoral level. He has written several researches andreview paper in reputed journals and has contributed several chapters inbooks on pharmaceutical and indigenous drugs. He is a member of various professional and academicbodies like Association of Pharmaceutical Teachers of India (APTI) and the Society of Pharmacognosy.Nagendra Singh Chauhan obtained his MPharm and PhD fromDepartment of Pharmaceutical Sciences, Dr. H.S. Gour University,Sagar in 2006 and 2011. He has around 14 years of research experience.He is presently working as Senior Scientific Officer Grade-II andGovernment Analyst at Drugs Testing Laboratory avam AnusandhanKendra, Raipur, Chhattisgarh, India. He has professional expertise innatural product isolation. He also has hands-on experience in varioustechniques like extraction, isolation, and purification of natural productsfrom plant extracts using various chromatographic techniques forseparation of compounds including column, LC-MS, chromatography,preparative TLC, and structure elucidation of natural products with thehelp of various techniques like UV, mass, IR, and NMR. He is wellversed with the design, conduct, and data treatment of various in vivoexperiments like aphrodisiac, antidiabetic, anti-stress, hair growth,BPH, hepatoprotective, and reproductive parameters. He has written more than 50 articles published innational and international journals and 20 book chapters. He has more than 1400 citations with h-index21 and i10 index of 32 (Google scholar) and scopus h-index 15; 669 citations. He is a member of variousprofessional and academic bodies like Society of Pharmacognosy, International Natural Product SciencesTaskforce (INPST) Society, SILAE: Società Italo-Latinoamericana di Etnomedicina (The ScientificNetwork on Ethnomedicine, Italy), Institutional Human ethical committee, and the Association ofPharmaceutical Teachers of India (APTI).

• ContentsPreface ..................................................................................................................................................... viiEditors ....................................................................................................................................................... ixContributors .............................................................................................................................................. xiSection I Drug Delivery Systems1. Novel Drug Delivery Systems for Phytoconstituents: Current and Future Prospects .............. 3Vikas Sharma, Madhu Gupta, Durgesh Nandini Chauhan, Nagendra Singh Chauhan,Ramesh K.Goyal, and Kamal Shah2. Nanocarriers Systems and Their Application for the Delivery of DifferentPhytoconstituents ........................................................................................................................... 9Ebru Altuntaş, Gülgün Yener, and Burcu Özkan3. Liposome-Based Nanocarrier System for Phytoconstituents .................................................... 45Ngoc Thuy Trang Le, Linh Phuong Tran Pham, Diem Huong Tran Nguyen, Ngoc Hoang Le,Tuong Vi Tran, Cuu Khoa Nguyen, and Dai Hai Nguyen4. Phytosomes as Novel Carriers of Herbal Extracts ...................................................................... 69Sevgi Güngör, Özlem Akbal-Dağıstan, Evren Algın Yapar, Murat Kartal, and Yıldız Özsoy5. Lipid-Based Nanoparticles: SLN, NLC, and MAD .................................................................... 81Rita Cortesi, Paolo Mariani, Markus Drechsler, and Elisabetta EspositoSection II Application of Phytodrug Delivery6. Phytosomes as Useful Drug Delivery Systems for Cosmeceutical Application ...................... 105Francesca Froiio, Agnese Gagliardi, Massimo Fresta, Donato Cosco, and Donatella Paolino7. Novel UV Filtering Agents for Next-Generation Cosmetics: From Phytochemicals toInorganic Nanomaterials ..............................................................................................................121Aditya Arya and Jayanti Jha8. Development of Ethosome Formulation for Topical Therapeutic Applications ..................... 137Mansoureh Nazari Vishkaei, Mohamed B. Khadeer Ahamed, and Amin Malik ShahAbdul Majid9. Application of Phytodrug Delivery in Anticancer Therapy ..................................................... 157Xiuhua Wang and Shirui MaoSection III Phytomolecule Drug Delivery10. Improved Silymarin Characteristics for Clinical Applications by Novel DrugDelivery Systems ........................................................................................................................... 195Maryam Tabarzad, Fatemeh Ghorbani-Bidkorbeh, and Tahereh Hosseinabadi11. Silymarin—A Scintillating Phytoantioxidant: Clinical Applications and Bio-deliveryProblems ........................................................................................................................................ 223Aditya Arya, Subhojit Paul, and Anamika Gangwar12. Innovative Delivery Systems for Andrographolide Delivery ................................................... 241A. C. Santos, J. A. D. Sequeira, F. Veiga, A. Figueiras, and A. J. Ribeiro13. Polymeric Colloidal Carriers for Natural Polyphenolic Compounds ......................................261Maria Rosaria Lauro, Teresa Musumeci, Francesca Sansone, Giovanni Puglisi, andRosario Pignatello14. Drug Delivery Systems for the Controlled Delivery of Berberine ........................................... 283Rosario Pignatello, Simona Cianciolo, and Agata K. Giuffrida15. Lipid-Based Nanoformulations from Plants for Sustainable Drug Delivery ......................... 301Ilaria Clemente, Ilaria Colzi, and Sara Falsini16. Nanotechnological-Based Drug Delivery System for Magical Molecule Curcumin:Delivery, Possibilities and Challenges .........................................................................................313Madhu Gupta, Vikas Sharma, Durgesh Nandini Chauhan, Nagendra Singh Chauhan,Kamal Shah, and Ramesh K. GoyalIndex .......................................................................................................................................................333

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