NMR of Proteins and Nucleic Acids

Kurt Wuthrich was a co-recipient of the 2003 Nobel Prize in Chemistry for his work on nuclear magnetic resonance technology and its application to protein analysis.

• Introduction and Survey. THE FOUNDATIONS: STRUCTURE AND NMR OF BIOPOLYMERS. NMR of Amino Acid Residues and Mononucleotides. NMR Spectra of Proteins and Nucleic Acids in Solution. The NMR Assignment Problem in Biopolymers. Two-Dimensional NMR With Proteins and Nucleic Acids. Nuclear Overhauser Enhancement (NOE) in Biopolymers. RESONANCE ASSIGNMENTS AND STRUCTURE DETERMINATION IN PROTEINS. NOE-Observable 1H-1H Distances in Proteins. Sequence-Specific Resonance Assignments in Proteins. Polypeptide Secondary Structures in Proteins by NMR. Three-Dimensional Protein Structures by NMR. RESONANCE ASSIGNMENTS AND STRUCTURE DETERMINATION IN NUCLEIC ACIDS. NOE-Observable 1H-1H Distances in Nucleic Acids. Resonance Assignments in Nucleic Acids Using Scalar Couplings. Nucleic Acid Conformation, 1H-1H Overhauser Effects, and Sequence-Specific Resonance Assignments. WITH NMR TO BIOPOLYMER CONFORMATION AND BEYOND. Conformation of Noncrystalline Proteins and Nucleic Acids. NMR Studies of Intermolecular Interactions with Biopolymers. References. Index.