Nitric Oxide (Donor/Induced) in Chemosensitization

Dr Bonavida has vast expertise and various reported publications in the field of tumor cell sensitization to chemotherapy (a total of greater than 500 publications) and in particular the novel role of Nitric Oxide (NO) donors in chemo-sensitization and reversal of drug resistance. In addition, he was the first scientist to co-organize an international meeting on the topic (First International Workshop on NO and Cancer, 2005).

• 1. Nitric Oxide Mediated Chemosensitization: Gene Therapy Versus Exogenous Introduction of NO Donors2. Nitric Oxide Donors Sensitize Resistant Cancer Cells to Apoptosis Induced by Chemotherapy: Molecular Mechanisms of Sensitization3. RRx-001 Reset: Chemoresensitization Via NO-Mediated M1 Macrophage Repolarization4. Nitric Oxide and Nitric Oxide-Donors in Pre-Clinical Studies of Breast and Prostate Cancer5. Evaluation of the Impact of Nitric Oxide on Resistance to Platinum-Based Chemotherapeutics6. Nitric oxide and platinum derivatives-based regimens for cancer treatment: from preclinical studies to clinical trials7. NO-H2S Releasing Chimeras as a Multifaceted Approach to Cancer Therapy8. Nitric Oxide-based Anticancer Therapeutics: The New Technologies of The Nanoparticles9. Nitric Oxide in Rectal Cancer: from Mice to Patients10. Chemoprotective and Chemosensitizing Effects of Nitric oxide and Other Biologically Active Gases in Breast Cancer Chemotherapy: Potential Implications11. Role of Nitric Oxide in Cancer Stem Cell Regulation and Metastasis 12. Nitric Oxide Interacting with Glutathione Transferases 13. Application of MRI to Study the Role of Nitric Oxide in Cancer Therapy14. S-Nitrosothiol Metabolism In Cancer And Therapeutic Implications