This book constitutes the refereed proceedings of the First International Conference on Next-Gen Computing and Communication Systems, ICNCS 2025, held in Jaipur, India, during April 18-19, 2025.The 8 full papers presented in this volume were carefully reviewed and selected from 134 submissions.They are organized into the following topical sections: Next-Gen Computing; Next-Gen Networking and Communication Systems; and Emerging Applications and Use Cases.