New Treatment Strategies for Dengue and Other Flaviviral Diseases

The Novartis Foundation is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research.

• Chair’s introduction (Charles Rice). Dengue/dengue hemorrhagic fever: history and current status (Duane J. Gubler).Discussion.Molecular biology of flaviviruses (Eva Harris, Katherine L. Holden, Dianna Edgil, Charlotta Polacek and Karen Clyde).Discussion.Development of novel antivirals against flaviviruses (Chinmay G. Patkar and Richard J. Kuhn).Discussion.Entry functions and antigenic structure of flavivirus envelope proteins Karin Stiasny, Stefan Kiermayr and Franz X. Heinz).Discussion.General discussion I.Multiple enzyme activities of flavivirus proteins (R. Padmanabhan, N. Mueller, E. Reichert, C. Yon, T. Teramoto, Y. Kono, R. Takhampunya, S. Ubol, N. Pattabiraman, B. Falgout, V. K. Ganesh and K. Murthy).Discussion.Towards the design of flavivirus helicase/NTPase inhibitors: crystallographic and mutagenesis studies of the dengue virus NS3 helicase catalytic domain (Ting Xu, Aruna Sampath, Alex Chao, Daying Wen, Max Nanao, Dahai Luo, Patrick Chene, Subhash G. Vasudevan and Julien Lescar).Discussion.Finding new medicines for flaviviral targets (Thomas H. Keller, Yen Liang Chen, John E. Knox, Siew Pheng Lim, Ngai Ling Ma, Sejal J. Patel, Aruna Sampath, Qing Yin Wang, Zheng Yin and Subhash G. Vasudevan).Discussion.Structural and functional analysis of dengue virus RNA (Diego Alvarez, Maria F. Lodeiro, Claudia Filomatori, Silvana Fucito, Juan Mondotte and Andrea Gamarnik).Discussion.Organization of flaviviral replicase proteins in virus induced membranes: a role for NS1’ in Japanese encephalitis virus RNA synthesis (Vijaya Satchidanandam, Pradeep Devappa Uchil and Priti Kumar).Discussion.CRM1 dependent nuclear export of dengue virus type-2 NS5 (Melinda J. Pryor, Stephen M. Rawlinson, Peter J. Wright and David A. Jans).Discussion.T cell responses and dengue haemorrhagic fever (Gavin Screaton and Juthathip Mongkolsapaya).Discussion.The evolutionary biology of dengue virus (Edward C. Holmes).Discussion.Developing vaccines against flavivirus diseases: past success, present hopes and future challenges (John R. Stephenson).Discussion.A genomics approach to understanding host response during dengue infection (Martin L. Hibberd, Ling Ling, Thomas Tolfvenstam, Wayne Mitchell, Chris Wong, Vladimir A. Kuznetsov, Joshy George, Swee-Hoe Ong, Yijun Ruan, Chia L Wei, Feng Gu, Joshua Fink, Andy Yip, Wei Liu, Mark Schreiber and Subhash G. Vasudevan).Discussion.Mouse and hamsters models rodent models for the study of therapy against flavivirus infections (Nathalie Charlier, Pieter Leyssen, Erik De Clercq and Johan Neyts).Discussion.Secretion of flaviviral non-structural protein NS1: from diagnosis to pathogenesis (S. Alcon-LePoder, P. Sivard, M.-T. Drouet, A. Talarmin, C. Rice and M. Flamand).Discussion.Final discussion.Index of contributors.Subject index.

"…this reviewer was highly moved by the painstaking investigations and careful evaluation of results by the participants of this symposium." (Journal of Tropical Pediatrics, February 2008) "This is an excellent update of many aspects of dengue and the difficult quest for treatment and prevention. It is a valuable resource for new researchers coming to this fascinating field." (Doody's Health Services)"…painstaking investigations and careful evaluation…" (Journal of Tropical Pediatrics, January 2007)"...provides an excellent summary of dengue/flavivirus research and is important for individual and institutions interested in emerging infectious diseases."  (Microbiology Today, November 2007)"…this reviewer was highly moved by the painstaking investigations and careful evaluation of results by the participants of this symposium." (Journal of Tropical Pediatrics, February 2008)