Del i serien Handbook of Experimental Pharmacology

New Approaches to Drug Discovery

Häftad, Engelska, 2018

AvUlrich Nielsch,Ulrike Fuhrmann,Stefan Jaroch

2 869 kr

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This volume gives an overview ofstate of the art technologies and future developments in the field ofpreclinical pharmaceutical research. The lead generation part as a next step focuses on the requirements andtechnologies to identify new small molecules as lead compounds for furtheroptimization;

Produktinformation

Utgivningsdatum2018-04-25
Mått155 x 235 x 18 mm
Vikt598 g
FormatHäftad
SpråkEngelska
SerieHandbook of Experimental Pharmacology
Antal sidor341
FörlagSpringer International Publishing AG
ISBN9783319804552

Tillhör följande kategorier

Kemi inom Naturvetenskap och teknik
Biovetenskap inom Naturvetenskap och teknik
Farmakologi inom Medicin

Preface.-Part 1. Historical View.- Drug discovery in the past and today.Part 2. Target Discovery.- Emerging target families:intractable targets. In vivo target validation especially for biologicaltargets. HR RNAi/High Content analysis.- Part 3. Lead generation and Optimization.- Sources for leads: natural products,libraries. Screening: assays, readout, technology. Impact of structuralbiology, fragment based screening/Virtual screening. Predictive in silico toolsof compound properties. High throughput synthesis. New compound classes:Protein-Protein Interaction. Sources for biological leads/Screening ofbiologicals.- Part 4. Test systems forEfficacy and Safety.- In vitro/ Cell based assays. Pharmacodynamic. Pharmacokinetic. Safety and toxicology. Impactof biomarkers/personalized medicine. Simulating in vivo drug effects.

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