Dr Jacob Peedicayil completed MBBS in 1984 and MD in pharmacology in 1991, both at the Christian Medical College, Vellore, India. From 1993 to 1995 he did a Post-Doctoral Fellowship at the Centre for Cellular and Molecular Biology, Hyderabad, India. From 1995 to 1998 he worked as a Research Fellow in the Department of Neurological Sciences, Christian Medical College, Vellore. Since 1998 he has been on the faculty of the Department of Pharmacology and Clinical Pharmacology, Christian Medical College, Vellore, becoming a professor in 2007. He does theoretical research on epigenetics, focusing on epigenetics in psychiatry. In addition, he is involved in experimental research in smooth muscle pharmacology. Dr Dennis R. Grayson received his PhD from the Department of Biochemistry at Wayne State University School of Medicine in 1984. He has been interested in mechanisms associated with gene expression for over 35 years. He joined the laboratory of Dr James E. Darnell at the Rockefeller University as a Post-Doctoral Fellow in 1984 to study cell-type specific transcription factors and their interaction with promoters and enhancers. In 1988, Dr Grayson joined the Fidia-Georgetown Institute for the Neurosciences at Georgetown University to study gene expression programs in neurons and continued this research program at Allegheny Singer Research Institutein Pittsburgh from 1995 to 1998. He continued his interests in psychiatry and joined the Psychiatric Institute at the University of Illinois in 1998. This represented a unique opportunity to pursue the molecular underpinnings of schizophrenia. Dr Grayson has received NRSA post-doctoral support, and R01 and K04 funding from the National Institutes of Health to support his work. He has published over 140 papers in peer-reviewed journals and is regularly invited to speak at numerous national and international meetings. He is currently Director of the Epigenetic Core of the Center for Alcohol Research in Epigenetics.

• PrefaceDag H. Yasui, Jacob Peedicayil and Dennis R. GraysonSection I. Neuropsychiatric Disorders and Epigenetics: General Aspects1. Introduction to Neuropsychiatric Disorders and EpigeneticsDag H. Yasui, Jacob Peedicayil and Dennis R. Grayson2. Environmental Factors and Epigenetics of Neuropsychiatric DisordersAnke Hoffmann and Dietmar Spengler3. Epigenetic Biomarkers in Neuropsychiatric DisordersChin-Chuen Lin, Tiao-Lai HuangSection II: Epigenetics of Neuropsychiatric Disorders4. Epigenetics and Cognitive Disorders -Translational AspectsFabio Coppedè5. Epigenetics in Pervasive Developmental Disorders - Translational AspectsTakeo Kubota6. Epigenetic causes of intellectual disability – the fragile X syndrome paradigmElisabetta Tabolacci, Giovanni Neri7. Epigenetics of Attention-Deficit Hyperactivity DisorderNader Perroud, Sébastien Weibel, Jean-Michel Aubry, Alexandre Dayer8. The epigenetics of brain aging and psychiatric disordersHuan Gong, Xiangru Xu9. Epigenetic therapy may alleviate cognitive deficits in Down syndrome by downregulating overexpressed chromosome 21 gene productsAlain D. Dekker, Peter P. De Deyn and Marianne G. Rots10. Epigenetics and Multiple SclerosisLara Kular, Gonçalo Castelo-Branco and Maja Jagodic11. Epigenetics and MigraineSiew Hua Gan and Munvar Miya Shaik12. The role of epigenetics in the pathophysiology of epilepsySung Min Nam and Kyung-Ok Cho13. Epigenetic Dysregulation in Brain Tumors and NeurodevelopmentMarco M. Hefti and Nadejda Tsankova14. Epigenetics and Cerebrovascular DiseasesCarolina Soriano-Tárraga, Jordi Jiménez-Conde and Jaume Roquer15. Epigenetics and Eating DisordersHelge Frieling, Vanessa Buchholz16. Epigenetics in ObesityBrian M. Shewchuk17. Epigenetics and Drug Addiction-Translational AspectsJian Feng18. Epigenetics and Alcohol Use DisordersSneha Sagarkar and Amul Sakharkar Section III: Summary and Outlook19. Summary and OutlookDag H. Yasui, Jacob Peedicayil and Dennis R. Grayson

Dr Jacob Peedicayil completed MBBS in 1984 and MD in pharmacology in 1991, both at the Christian Medical College, Vellore, India. From 1993 to 1995 he did a Post-Doctoral Fellowship at the Centre for Cellular and Molecular Biology, Hyderabad, India. From 1995 to 1998 he worked as a Research Fellow in the Department of Neurological Sciences, Christian Medical College, Vellore. Since 1998 he has been on the faculty of the Department of Pharmacology and Clinical Pharmacology, Christian Medical College, Vellore, becoming a professor in 2007. He does theoretical research on epigenetics, focusing on epigenetics in psychiatry. In addition, he is involved in experimental research in smooth muscle pharmacology. Dr Dennis R. Grayson received his PhD from the Department of Biochemistry at Wayne State University School of Medicine in 1984. He has been interested in mechanisms associated with gene expression for over 35 years. He joined the laboratory of Dr James E. Darnell at the Rockefeller University as a Post-Doctoral Fellow in 1984 to study cell-type specific transcription factors and their interaction with promoters and enhancers. In 1988, Dr Grayson joined the Fidia-Georgetown Institute for the Neurosciences at Georgetown University to study gene expression programs in neurons and continued this research program at Allegheny Singer Research Institutein Pittsburgh from 1995 to 1998. He continued his interests in psychiatry and joined the Psychiatric Institute at the University of Illinois in 1998. This represented a unique opportunity to pursue the molecular underpinnings of schizophrenia. Dr Grayson has received NRSA post-doctoral support, and R01 and K04 funding from the National Institutes of Health to support his work. He has published over 140 papers in peer-reviewed journals and is regularly invited to speak at numerous national and international meetings. He is currently Director of the Epigenetic Core of the Center for Alcohol Research in Epigenetics.

• PrefaceDag H. Yasui, Jacob Peedicayil and Dennis R. GraysonSection I. Neuropsychiatric Disorders and Epigenetics: General Aspects1. Introduction to Neuropsychiatric Disorders and EpigeneticsDag H. Yasui, Jacob Peedicayil and Dennis R. Grayson2. Environmental Factors and Epigenetics of Neuropsychiatric DisordersAnke Hoffmann and Dietmar Spengler3. Epigenetic Biomarkers in Neuropsychiatric DisordersChin-Chuen Lin, Tiao-Lai HuangSection II: Epigenetics of Neuropsychiatric Disorders4. Epigenetics and Cognitive Disorders -Translational AspectsFabio Coppedè5. Epigenetics in Pervasive Developmental Disorders - Translational AspectsTakeo Kubota6. Epigenetic causes of intellectual disability – the fragile X syndrome paradigmElisabetta Tabolacci, Giovanni Neri7. Epigenetics of Attention-Deficit Hyperactivity DisorderNader Perroud, Sébastien Weibel, Jean-Michel Aubry, Alexandre Dayer8. The epigenetics of brain aging and psychiatric disordersHuan Gong, Xiangru Xu9. Epigenetic therapy may alleviate cognitive deficits in Down syndrome by downregulating overexpressed chromosome 21 gene productsAlain D. Dekker, Peter P. De Deyn and Marianne G. Rots10. Epigenetics and Multiple SclerosisLara Kular, Gonçalo Castelo-Branco and Maja Jagodic11. Epigenetics and MigraineSiew Hua Gan and Munvar Miya Shaik12. The role of epigenetics in the pathophysiology of epilepsySung Min Nam and Kyung-Ok Cho13. Epigenetic Dysregulation in Brain Tumors and NeurodevelopmentMarco M. Hefti and Nadejda Tsankova14. Epigenetics and Cerebrovascular DiseasesCarolina Soriano-Tárraga, Jordi Jiménez-Conde and Jaume Roquer15. Epigenetics and Eating DisordersHelge Frieling, Vanessa Buchholz16. Epigenetics in ObesityBrian M. Shewchuk17. Epigenetics and Drug Addiction-Translational AspectsJian Feng18. Epigenetics and Alcohol Use DisordersSneha Sagarkar and Amul Sakharkar Section III: Summary and Outlook19. Summary and OutlookDag H. Yasui, Jacob Peedicayil and Dennis R. Grayson

Dr Jacob Peedicayil completed MBBS in 1984 and MD in pharmacology in 1991, both at the Christian Medical College, Vellore, India. From 1993 to 1995 he did a Post-Doctoral Fellowship at the Centre for Cellular and Molecular Biology, Hyderabad, India. From 1995 to 1998 he worked as a Research Fellow in the Department of Neurological Sciences, Christian Medical College, Vellore. Since 1998 he has been on the faculty of the Department of Pharmacology and Clinical Pharmacology, Christian Medical College, Vellore, becoming a professor in 2007. He does theoretical research on epigenetics, focusing on epigenetics in psychiatry. In addition, he is involved in experimental research in smooth muscle pharmacology. Dr Dennis R. Grayson received his PhD from the Department of Biochemistry at Wayne State University School of Medicine in 1984. He has been interested in mechanisms associated with gene expression for over 35 years. He joined the laboratory of Dr James E. Darnell at the Rockefeller University as a Post-Doctoral Fellow in 1984 to study cell-type specific transcription factors and their interaction with promoters and enhancers. In 1988, Dr Grayson joined the Fidia-Georgetown Institute for the Neurosciences at Georgetown University to study gene expression programs in neurons and continued this research program at Allegheny Singer Research Institutein Pittsburgh from 1995 to 1998. He continued his interests in psychiatry and joined the Psychiatric Institute at the University of Illinois in 1998. This represented a unique opportunity to pursue the molecular underpinnings of schizophrenia. Dr Grayson has received NRSA post-doctoral support, and R01 and K04 funding from the National Institutes of Health to support his work. He has published over 140 papers in peer-reviewed journals and is regularly invited to speak at numerous national and international meetings. He is currently Director of the Epigenetic Core of the Center for Alcohol Research in Epigenetics.

• PrefaceDag H. Yasui, Jacob Peedicayil and Dennis R. GraysonSection I. Neuropsychiatric Disorders and Epigenetics: General Aspects1. Introduction to Neuropsychiatric Disorders and EpigeneticsDag H. Yasui, Jacob Peedicayil and Dennis R. Grayson2. Environmental Factors and Epigenetics of Neuropsychiatric DisordersAnke Hoffmann and Dietmar Spengler3. Epigenetic Biomarkers in Neuropsychiatric DisordersChin-Chuen Lin, Tiao-Lai HuangSection II: Epigenetics of Neuropsychiatric Disorders4. Epigenetics and Cognitive Disorders -Translational AspectsFabio Coppedè5. Epigenetics in Pervasive Developmental Disorders - Translational AspectsTakeo Kubota6. Epigenetic causes of intellectual disability – the fragile X syndrome paradigmElisabetta Tabolacci, Giovanni Neri7. Epigenetics of Attention-Deficit Hyperactivity DisorderNader Perroud, Sébastien Weibel, Jean-Michel Aubry, Alexandre Dayer8. The epigenetics of brain aging and psychiatric disordersHuan Gong, Xiangru Xu9. Epigenetic therapy may alleviate cognitive deficits in Down syndrome by downregulating overexpressed chromosome 21 gene productsAlain D. Dekker, Peter P. De Deyn and Marianne G. Rots10. Epigenetics and Multiple SclerosisLara Kular, Gonçalo Castelo-Branco and Maja Jagodic11. Epigenetics and MigraineSiew Hua Gan and Munvar Miya Shaik12. The role of epigenetics in the pathophysiology of epilepsySung Min Nam and Kyung-Ok Cho13. Epigenetic Dysregulation in Brain Tumors and NeurodevelopmentMarco M. Hefti and Nadejda Tsankova14. Epigenetics and Cerebrovascular DiseasesCarolina Soriano-Tárraga, Jordi Jiménez-Conde and Jaume Roquer15. Epigenetics and Eating DisordersHelge Frieling, Vanessa Buchholz16. Epigenetics in ObesityBrian M. Shewchuk17. Epigenetics and Drug Addiction-Translational AspectsJian Feng18. Epigenetics and Alcohol Use DisordersSneha Sagarkar and Amul Sakharkar Section III: Summary and Outlook19. Summary and OutlookDag H. Yasui, Jacob Peedicayil and Dennis R. Grayson