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Phytochemicals are naturally occurring bioactive compounds found in edible fruits, plants, vegetables, and herbs. Unlike vitamins and minerals, phytochemicals are not needed for the maintenance of cell viability, but they play a vital role in protecting neural cells from inflammation and oxidative stress associated with normal aging and acute and chronic age-related brain diseases. Neuroprotective Effects of Phytochemicals in Neurological Disorders explores the advances in our understanding of the potential neuroprotective benefits that these naturally occurring chemicals contain.Neuroprotective Effects of Phytochemicals in Neurological Disorders explores the role that a number of plant-based chemical compounds play in a wide variety of neurological disorders. Chapters explore the impact of phytochemicals on neurotraumatic disorders, such as stroke and spinal cord injury, alongside neurodegenerative diseases such as Alzheimer's and Parkinson's Disease, as well as neuropsychiatric disorders such as depression and schizophrenia. The chapters and sections of this book provide the reader with a big picture view of this field of research.Neuroprotective Effects of Phytochemicals in Neurological Disorders aims to present readers with a comprehensive and cutting edge look at the effects of phytochemicals on the brain and neurological disorders in a manner useful to researchers, neuroscientists, clinical nutritionists, and physicians.
Tahira Farooqui and Akhlaq A. Farooqui, The Ohio State University, Columbus, OH, USA
Contributors xiPreface xixAcknowledgments xxiii1 Use of Phytochemicals against Neuroinflammation 1Wei-Yi Ong, Tahira Farooqui, Christabel Fung-Yih Ho, Yee-Kong Ng, and Akhlaq A. Farooqui2 Flavonoids in Transgenic Alzheimer’s Disease Mouse Models: Current Insights and Future Perspectives 43Angélica Maria Sabogal-Guáqueta, Edison Osorio, and Gloria Patricia Cardona-Gómez3 Neuroprotective Effects of Polyphenols in Aging and Age-Related Neurological Disorders 65Giulia Corona and David Vauzour4 Indian Herbs and their Therapeutic Potential against Alzheimer’s Disease 79Navrattan Kaur, Bibekananda Sarkar, Iqbal Gill, Sukhchain Kaur, Sunil Mittal, Monisha Dhiman, Prasad K. Padala, Regino Perez-Polo, and Anil K. Mantha5 Garlic and its Effects in Neurological Disorders 113Akhlaq A. Farooqui and Tahira Farooqui6 Effects of Extra-Virgin Olive Oil in Neurological Disorders 133Akhlaq A. Farooqui and Tahira Farooqui7 Ginger Components as Anti-Alzheimer Drugs: Focus on Drug Design 149Faizul Azam8 Phytomedicine: A Possible Tool for Alzheimer’s Disease Therapeutics 167Jai Malik9 Effects of Phytochemicals on Diabetic Retinoneuropathy 199Mohammad Shamsul Ola, Mohd Imtiaz Nawaz, and Abdullah S. Alhomida10 Herbal Drugs: A New Hope for Huntington’s Disease 213Jai Malik11 Neuroprotective Properties of Dietary Polyphenols in Parkinson’s Disease 243Altaf S. Darvesh, McKenna McClure, Prabodh Sadana, Chris Paxos, Werner J. Geldenhuys, Joshua D. Lambert, Tariq M. Haqqi, and Jason R. Richardson12 Potential of Polyphenols in the Treatment of Major Depression: Focus on Molecular Aspects 265Ashish Dhir13 Effect of Phytochemicals on Diabetes-Related Neurological Disorders 283Abubakar Mohammed, Kanti Bhooshan Pandey, and Syed Ibrahim Rizvi14 Neuroprotective Effects of Extra-Virgin Olive Oil and its Components in Alzheimer’s Disease 299Alaa H. Abuznait, Hisham Qosa, Loqman A. Mohamed, Yazan S. Batarseh, and Amal Kaddoumi15 Protective Role of Black-Tea Extract in a Transgenic Drosophila Model of Parkinson’s Disease 317Yasir Hasan Siddique16 Apitherapy: Therapeutic Effects of Propolis on Neurological Disorders 335Tahira Farooqui and Akhlaq A. Farooqui17 Molecular Mechanisms behind the Beneficial Activity of Polyunsaturated Fatty Acids in Alzheimer’s Disease and Related Conditions 359Undurti N. Das18 Prevention of Neuroinflammation by Resveratrol: Focus on Experimental Models and Molecular Mechanisms 377Justine Renaud and Maria-Grazia Martinoli19 Modulation of the Estradiol and Neprilysin Pathways by Resveratrol in a Lipopolysaccharide Model of Cognitive Impairment 395Nesrine S. El Sayed20 Neuroprotective Effect of Resveratrol in Cerebral Ischemia 407Ghosh Nilanjan, Ghosh Rituparna, Mandal C. Subhash, and Mahadeb Pal21 Effects of Nobiletin in Animal Models of Cognitive Impairment: Current Insights and Future Perspectives 421Akira Nakajima, Yasushi Ohizumi, and Kiyofumi Yamada22 Potential Neuroprotective Effects of Curcumin against Dementia 435Natascia Brondino, Laura Fusar-Poli, Cristina Panisi, and Pierluigi Politi23 Neuroprotective Activity of Curcumin and Emblica officinalis Extract against Carbofuran-Induced Neurotoxicity in Wistar Rats 447Ramadasan Kuttan and P.P. Binitha24 Potential Use of Curcuminoids for the Treatment of Alzheimer’s Disease 463Touqeer Ahmed, Sana Javed, Ameema Tariq, and Anwarul-Hassan Gilani25 Prevention by Curcumin of Neuroinflammation in Intracerebral Hemorrhage 489Yujie Chen and Hua Feng26 Effect of Polyphenols on Protein Misfolding 501Rona Banerjee27 Molecular Mechanisms Involved in the Neuroprotective Action of Phytochemicals 515Aditya Sunkaria, Aarti Yadav, Sunil Kumar Sharma, and Rajat Sandhir28 Nutraceuticals and Cognitive Dysfunction: Focus on Alzheimer’s Disease 561Virginia Boccardi, Clara Tinarelli, and Patrizia Mecocci29 Summary and Perspective 581Tahira Farooqui and Akhlaq A. FarooquiIndex 595
Tahira Farooqui, Akhlaq A. Farooqui, USA) Farooqui, Tahira (Research Scientist, Department of Entomology/Center for Molecular Neurobiology, College of Biological Sciences, The Ohio State University, Columbus, OH, USA) Farooqui, Akhlaq A. (Research Scientist, Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, OH, Akhlaq A Farooqui
Tahira Farooqui, Akhlaq A. Farooqui, USA) Farooqui, Tahira (Research Scientist, Department of Entomology/Center for Molecular Neurobiology, College of Biological Sciences, The Ohio State University, Columbus, OH, USA) Farooqui, Akhlaq A. (Research Scientist, Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, OH