Neuropathic Pain

Dr. Páll Karlsson is an Associate Professor at Aarhus University and leads the Molecular Mechanisms group at the Danish Pain Research Center. His research focuses on the molecular and cellular mechanisms underlying neuropathic pain, with a particular emphasis on human tissue-based approaches, including skin biopsies, advanced immunohistochemistry, and spatial transcriptomics. He integrates detailed clinical phenotyping with multi-omics analyses to investigate disease mechanisms in diabetic neuropathy and related conditions. His work aims to improve understanding of the biological processes that distinguish painful from painless neuropathy and to support the identification of potential therapeutic targets through translational human studies.

• ForewordJan Rosner and Páll Karlsson1. NeuroanatomyJulian Chase Motzkin, Andrew Crowther and Allan Basbaum2. Clinical Diagnosis and SyndromesTroels S. Jensen3. Quantitative Sensory TestingJulia Forstenpointner and Roy Freeman4. NeuroimagingKaren Deborah Davis and Rima El-Sayed5. Placebo and ExpectationLene Vase and Sigrid Juhl Lunde6. Small Fiber NeuropathyDennis Kool, Stephen Waxman and Catharina Faber7. In Vitro ModelsMastaneh Nochi and Franziska Denk8. Molecular MechanismsPaola Pacifico and Daniela Menichella9. NeuroinflammationPaulina S. Scheuren and Margarita Calvo10. Animal ModelsRebecca Seal11. PharmacologyJan Rosner and Nanna Brix Finnerup12. Psychological, Physical and Complementary TherapiesNell Norman-Nott, Sylvia Gustin and Aidan Cashin13. NeuromodulationDaniel Ciampi de Andrade