• I. Neuroinflammatory Mechanisms.- 1 Microglia: Roles of Microglia in Chronic Neurodegenerative Diseases.- 2 Apoptosis vs Nonapoptotic Mechanisms in Neurodegeneration.- 3 Role(s) of Mitogen and Stress-Activated Kinases in Neurodegeneration.- 4 Roles of Chemokines and Their Receptors in Neuroinflammation.- 5 Neurotoxic Mechanisms of Nitric Oxide.- 6 Chronic Intracerebral LPS as a Model of Neuroinflammation.- 7 Peroxisome Proliferator-Activated Receptor Gamma Agonists: Potential Therapeutic Agents for Neuroinflammation.- 8 Neuroinflammation-Mediated Neurotoxin Production in Neurodegenerative Diseases: Potential of Nitronesas Therapeutics.- II. Stroke and TBI.- 9 Inflammation and Potential Anti-Inflammatory Approaches in Stroke.- 10 Neuroinflammation as an Important Pathogenic Mechanism in Spinal Cord Injury.- 11 Type IV Collagenases and Blood-Brain Barrier Breakdown in Brain Ischemia.- III Alzheimer’s Disease.- 12 Neuroinflammatory Environments Promote Amyloid-? Deposition and Posttranslational Modification.- 13 Microglial Responses in Alzheimer’s Disease: Recent Studies in Transgenic Mice and Alzheimer’s Disease Brains.- 14 The Amyloid Hypothesis of Cognitive Dysfunction.- 15 The Cerebellum in AD: A Case for Arrested Neuroinflammation?.- 16 The Neuroinflammatory Components of the Trimethyltin (TMT) Model of Hippocampal Neurodegeneration.- 17 Inflammation and Cyclo-Oxygenase in Alzheimer’s Disease: Experimental Approaches and Therapeutic Implications.- IV. Multiple Sclerosis.- 18 Experimental Autoimmune Encephalomyelitis.- 19 Neuroimmunologic Mechanisms in the Etiology of Multiple Sclerosis.- 20 In Vivo Imaging of Neuroinflammation in Neurodegenerative Diseases.- V. Parkinson’s and Huntington’s Diseases.- 21 Inflammatory Mechanisms in Parkinson’s Disease.- 22 Neuroinflammatory Components of the 3-Nitropropionic Acid Model of Striatal Neurodegeneration.

Review of the first edition: "...will reach a wide audience including basic and clinical neuroscientists...fills a significant gap in the literature...provides an excellent starting point, and offers insight into the rapid pace of discovery within a field which influences most aspects of nervous system function."-Nature Medicine "...fills a significant gap in the literature...provides an excellent starting point..." -Nature Medicine "...will be useful to a wide variety of researchers and clinicians, particularly [those] interested in neurodegenerative disorders ..." -Neurological Research "...provides a thorough overview of cells and mechanisms of brain inflammation, their role in disease and future therapeutic avenues to overcome it." -Microbiology Today "...a timely addition that will aid our understanding today." -Receptors & Signal Transduction

• I. Neuroinflammatory Mechanisms.- 1 Microglia: Roles of Microglia in Chronic Neurodegenerative Diseases.- 2 Apoptosis vs Nonapoptotic Mechanisms in Neurodegeneration.- 3 Role(s) of Mitogen and Stress-Activated Kinases in Neurodegeneration.- 4 Roles of Chemokines and Their Receptors in Neuroinflammation.- 5 Neurotoxic Mechanisms of Nitric Oxide.- 6 Chronic Intracerebral LPS as a Model of Neuroinflammation.- 7 Peroxisome Proliferator-Activated Receptor Gamma Agonists: Potential Therapeutic Agents for Neuroinflammation.- 8 Neuroinflammation-Mediated Neurotoxin Production in Neurodegenerative Diseases: Potential of Nitronesas Therapeutics.- II. Stroke and TBI.- 9 Inflammation and Potential Anti-Inflammatory Approaches in Stroke.- 10 Neuroinflammation as an Important Pathogenic Mechanism in Spinal Cord Injury.- 11 Type IV Collagenases and Blood-Brain Barrier Breakdown in Brain Ischemia.- III Alzheimer’s Disease.- 12 Neuroinflammatory Environments Promote Amyloid-? Deposition and Posttranslational Modification.- 13 Microglial Responses in Alzheimer’s Disease: Recent Studies in Transgenic Mice and Alzheimer’s Disease Brains.- 14 The Amyloid Hypothesis of Cognitive Dysfunction.- 15 The Cerebellum in AD: A Case for Arrested Neuroinflammation?.- 16 The Neuroinflammatory Components of the Trimethyltin (TMT) Model of Hippocampal Neurodegeneration.- 17 Inflammation and Cyclo-Oxygenase in Alzheimer’s Disease: Experimental Approaches and Therapeutic Implications.- IV. Multiple Sclerosis.- 18 Experimental Autoimmune Encephalomyelitis.- 19 Neuroimmunologic Mechanisms in the Etiology of Multiple Sclerosis.- 20 In Vivo Imaging of Neuroinflammation in Neurodegenerative Diseases.- V. Parkinson’s and Huntington’s Diseases.- 21 Inflammatory Mechanisms in Parkinson’s Disease.- 22 Neuroinflammatory Components of the 3-Nitropropionic Acid Model of Striatal Neurodegeneration.

Review of the first edition: "...will reach a wide audience including basic and clinical neuroscientists...fills a significant gap in the literature...provides an excellent starting point, and offers insight into the rapid pace of discovery within a field which influences most aspects of nervous system function."-Nature Medicine "...fills a significant gap in the literature...provides an excellent starting point..." -Nature Medicine "...will be useful to a wide variety of researchers and clinicians, particularly [those] interested in neurodegenerative disorders ..." -Neurological Research "...provides a thorough overview of cells and mechanisms of brain inflammation, their role in disease and future therapeutic avenues to overcome it." -Microbiology Today "...a timely addition that will aid our understanding today." -Receptors & Signal Transduction

• I. Neuroinflammatory Mechanisms.- 1 Microglia: Roles of Microglia in Chronic Neurodegenerative Diseases.- 2 Apoptosis vs Nonapoptotic Mechanisms in Neurodegeneration.- 3 Role(s) of Mitogen and Stress-Activated Kinases in Neurodegeneration.- 4 Roles of Chemokines and Their Receptors in Neuroinflammation.- 5 Neurotoxic Mechanisms of Nitric Oxide.- 6 Chronic Intracerebral LPS as a Model of Neuroinflammation.- 7 Peroxisome Proliferator-Activated Receptor Gamma Agonists: Potential Therapeutic Agents for Neuroinflammation.- 8 Neuroinflammation-Mediated Neurotoxin Production in Neurodegenerative Diseases: Potential of Nitronesas Therapeutics.- II. Stroke and TBI.- 9 Inflammation and Potential Anti-Inflammatory Approaches in Stroke.- 10 Neuroinflammation as an Important Pathogenic Mechanism in Spinal Cord Injury.- 11 Type IV Collagenases and Blood-Brain Barrier Breakdown in Brain Ischemia.- III Alzheimer’s Disease.- 12 Neuroinflammatory Environments Promote Amyloid-? Deposition and Posttranslational Modification.- 13 Microglial Responses in Alzheimer’s Disease: Recent Studies in Transgenic Mice and Alzheimer’s Disease Brains.- 14 The Amyloid Hypothesis of Cognitive Dysfunction.- 15 The Cerebellum in AD: A Case for Arrested Neuroinflammation?.- 16 The Neuroinflammatory Components of the Trimethyltin (TMT) Model of Hippocampal Neurodegeneration.- 17 Inflammation and Cyclo-Oxygenase in Alzheimer’s Disease: Experimental Approaches and Therapeutic Implications.- IV. Multiple Sclerosis.- 18 Experimental Autoimmune Encephalomyelitis.- 19 Neuroimmunologic Mechanisms in the Etiology of Multiple Sclerosis.- 20 In Vivo Imaging of Neuroinflammation in Neurodegenerative Diseases.- V. Parkinson’s and Huntington’s Diseases.- 21 Inflammatory Mechanisms in Parkinson’s Disease.- 22 Neuroinflammatory Components of the 3-Nitropropionic Acid Model of Striatal Neurodegeneration.

Review of the first edition: "...will reach a wide audience including basic and clinical neuroscientists...fills a significant gap in the literature...provides an excellent starting point, and offers insight into the rapid pace of discovery within a field which influences most aspects of nervous system function."-Nature Medicine "...fills a significant gap in the literature...provides an excellent starting point..." -Nature Medicine "...will be useful to a wide variety of researchers and clinicians, particularly [those] interested in neurodegenerative disorders ..." -Neurological Research "...provides a thorough overview of cells and mechanisms of brain inflammation, their role in disease and future therapeutic avenues to overcome it." -Microbiology Today "...a timely addition that will aid our understanding today." -Receptors & Signal Transduction