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As indicated by its title, this monograph deals chiefly with morphologically recognizable deviations from the normal anatomical condition of the human CNS. The AD process commences much earlier than the clinically recognizable phase of the disorder, and its timeline includes an extended preclinical phase.
Prologue.- General Morphology of Alzheimer-associated intraneuronal pathology.- Consistent and systematic changes in the distribution pattern of intraneuronal inclusions render staging possible.- Basic organization of involved structures.- Presymptomatic stages.- General morphology of Alzheimer-associated extracellular pathology.- Symptomatic stages.- The progression of cortical lesions mimics the pattern of myelination in reverse order.- Tauopathies.- CSF biomarkers and imaging techniques.- The staging hypothesis: assumptions, challenges, potential.- Technical considerations.