Natural Products and their Bioactives in Antidiabetic Drug Discovery

Inbunden, Engelska, 2023

Av Kanti Bhooshan Pandey, Maitree Suttajit, Pinar Atukeren, India) Pandey, Kanti Bhooshan (CSIR-Central Salt & Marine Chemicals Research Institute, Bhavnagar, Gujarat, Thailand) Suttajit, Maitree (University of Phayao, Phayao Province, Turkey) Atukeren, Pinar (Istanbul University-Cerrahpasa, Istanbul

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Natural Products and their Bioactives in Antidiabetic Drug Discovery Enables researchers to effectively understand and use bioactive compounds to target, prevent, and manage diabetes Natural Products and Their Bioactives in Antidiabetic Drug Discovery provides readers with an overview of recent research in new drug discovery against diabetic complications based on bioactives from NPs, bridging the gap between the public research institutes and private companies working to find drugs to treat diabetes. To aid in reader comprehension, the text includes case studies and illustrated examples in relevant chapters. Part one presents chapters on fundamental concepts of diabetes mellitus (DM) and recent drug discovery progress along with the various druggable targets and challenges. Part two covers bioactive compounds targeting Type-1 Diabetes. Part three focuses on Type-2 Diabetes. In Part four, the contributors address gestational DM prevention and management with natural compounds. Written by a global team of experts in the field, Natural Products and their Bioactives in Antidiabetic Drug Discovery covers sample topics such as: Obesity risk factor in patients with T1DM and possible role of nutritional therapy in its managementUse of natural non-insulin drugs as a novel approach to enhance therapeutic outcomes against T1DMEffectiveness of functional foods in intervening the diabetic complications and realistic results in clinical trialsImplementation of nanotechnology in improving the bioavailability and reducing the threshold dose of bioactive compoundsVarious antidiabetic mechanisms of action of different polyphenols and immunomodulatory role of NPs bioactives relevance in T1DM therapyEffects of natural products on genetics of gestational diabetesWith comprehensive coverage of recent research in new drug discovery against diabetic complications based on bioactives from NPs, Natural Products and Their Bioactives in Antidiabetic Drug Discovery is an essential resource for researchers and professionals involved in drug discovery and development, health care, medicinal chemistry, phytochemistry, plant science, and toxicology.

Produktinformation

Utgivningsdatum2023-07-18
Mått152 x 231 x 23 mm
Vikt894 g
FormatInbunden
SpråkEngelska
Antal sidor352
FörlagJohn Wiley & Sons Inc
ISBN9781119983316

Tillhör följande kategorier

Biokemi inom Naturvetenskap och teknik
Organisk kemi inom Naturvetenskap och teknik
Farmakologi inom Medicin

Kanti Bhooshan Pandey, PhD, is a Senior Scientist and Assistant Professor in the Faculty of Biological Sciences, AcSIR; CSIR-Central Salt & Marine Chemicals Research Institute, Gujarat, India. Maitree Suttajit, PhD, is Professor Emeritus previously at School of Medicine, Chiang Mai University and later at School of Medical Sciences, University of Phayao, Thailand. Pinar Atukeren, PhD, is a senior Professor in Medical Biochemistry teaching in İstanbul Üniversitesi-Cerrahpaşa, Cerrahpaşa Faculty of Medicine, Department of Medical Biochemistry, and also the Founding Dean of İstanbul Üniversitesi-Cerrahpaşa, Faculty of Pharmacy, Turkey.

List of Contributors viiiPreface xiiPart I Fundamental Concepts of Diabetes Mellitus and Drug Discovery Process 11 Diabetes Mellitus and Natural Product-based Drug Discovery: Novel Directions 3David J. Newman2 Marine Natural Products in the Management of Diabetes Mellitus 18Murali Krishna Paidi, Kanchan Siddaprasad Udata, and Subir Kumar Mandal3 Carbohydrate-based Antidiabetic Agents from Natural Products 38Sandeep Singh4 Functional Foods in Clinical Trials in the Intervention of Diabetes Complications 49Bavani Arumugam and Umah Rani Kuppusamy5 Role of Nanotechnology in Refining the Antidiabetic Activities of Plant Derived Bioactives 74Sonam Mishra, Ravindra Dhar, Maitree Suttajit, and Bishnu Kumar PandeyPart II Bioactive Compounds Against Type 1 Diabetes Mellitus 976 Epidemiology and Genetics of Type 1 Diabetes Mellitus: The Effect of the Mediterranean Diet 99Bilge Nur Col and Muveddet Emel Alphan7 The Emerging Role of Plant Polyphenols in the Management of Type 1 Diabetes Mellitus 113S. Asha Devi, Suparna Mandal, and S. Raja Sekhar8 Bioactives as Modulators of β-cells and Immunity in Therapy of Type 1 Diabetes Mellitus 136Shashank Kumar Ojha9 Obesity in Type 1 Diabetes Mellitus: Clinical Impact and Nutritional Therapy 147Gülen Ecem Kalkan and Burcu Ateş Özcan10 Protective Effects of Natural Non-insulin Drugs against Type 1 Diabetes Mellitus 164Waseem Hassan, Faraza Javaid, Andleeb Shahzadi, and Sahar BakhtPart III Bioactive Compounds Against Type 2 Diabetes Mellitus 17711 Age-induced Biomarkers of Oxidative Stress in Type 2 Diabetes Mellitus: Role of Plant Polyphenols 179Brahm Kumar Tiwari and Kanti Bhooshan Pandey12 Bioactives from Clove Oil for Antibacterial Wound Dressings for the Treatment and Management of Wounds in Type 2 Diabetes Mellitus 195Andleeb Shahzadi and Haktan Sonmez13 Nutritional Features and Bioactivities of Thymoquinone against Type 2 Diabetes Mellitus 211Pınar Atukeren14 Effect of Resveratrol and Catechins in Maintaining Redox Homeostasis during Type 2 Diabetes Mellitus 219Prachee Dubey and Geeta Watal15 Cannabis: Action Mechanisms and Potential Roles in the Management of Type 2 Diabetes Mellitus 232Karolin Yanar and Zeynep Mine Coşkun YazıcıPart IV Gestational Diabetes: Prevention and Management by Natural Compounds 24516 Epidemiology of Gestational Diabetes Mellitus: Preventive Significance of Dietary Pattern 247Burcu Yeşilkaya17 Biomarkers of Gestational Diabetes Mellitus, Dietary Polyphenols, and Drug Discovery 260Mansi Gandhi18 Medicinal and Aromatic Plants in the Prevention of Gestational Diabetes and Associated Consequences: Current Insights 275Jigeesha Mishra, Kanti Bhooshan Pandey, and Shailendra Kumar Srivastava19 Enhancement of Insulin Sensitivity and Management of Lipid Disorders during Gestational Diabetes Mellitus: Role of Capsaicin 294Banu Orta-Yilmaz, Ahu Korkut, and Yasemin Aydin20 Effects of Natural Products on the Genetics of Gestational Diabetes Mellitus 308Onur BaykaraIndex 321