Natural Compounds as Drugs, Volume II

• Activation of fungal silent gene clusters: A new avenue to drug discovery.- Total synthesis studies on macrocyclic pipecolic acid natural products: FK506, the antascomicins and rapamycin.- Application of natural product-inspired diversity-oriented synthesis to drug discovery.- Cheminformatics analysis of natural products: Lessons from nature inspiring the design of new drugs.- Chemical-genetic approaches for exploring the mode of action of natural products.- Epothilones as lead structures for new anticancer drugs — pharmacology, fermentation, and structure-activity-relationships.- Histone deacetylase inhibitors from microorganisms: the Astellas experience.- Ascomycete derivative to MS therapeutic: S1P receptor modulator FTY720.- Artemisinin — an innovative cornerstone for anti-malaria therapy.

From the reviews: "This second compilation highlights innovative trends in natural products research. ... provide very diverging aspects from molecular biology to practical questions such as production optimization strategies. ... This well-designed volume provides reviews of constant quality in the important field of modern drug research written by an international crew of experts. ... Figures / schemes (numerous formulas) and tables are useful and well organized. ... I recommend this book to anyone interested in modern drug research. It would best be suited for science and industry libraries." (Eckart Eich, Economic Botany, Vol. 63 (4), 2009)