Nanoplatform-Based Molecular Imaging

Xiaoyuan Chen received his PhD in chemistry from the University of Idaho and was an Associate Professor of Radiology in the School of Medicine at Stanford University before joining the National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH) as a senior investigator and the Laboratory of Molecular Imaging and Nanomedicine (LOMIN) as chief. He is the author of more than 200 scholarly articles and has edited one book to date. Dr. Chen's research interests include developing and validating novel molecular imaging probes (nanoparticles, antibodies, proteins, peptides, and small organic molecules) for better understanding of the biology, early diagnosis of disease, monitoring therapy response, and guiding drug discovery and development.

• Preface. Acknowledgments.Contributors.Part I Basics of Molecular Imaging and Nanobiotechnology.1. Basic Principles of Molecular Imaging (Sven H. Hausner).2. Synthesis of Nanomaterials as a Platform for Molecular Imaging (Jinhao Gao, Jin Xie, Bing Xu, and Xiaoyuan Chen).3. Nanoparticle Surface Modification and Bioocnjugation (Jin Xie, Jinhao Gao, Mark Michalski, and Xiaoyuan Chen).4. Biodistribution and Pharmacokinetics of Nanoprobes (Nagesh Kolishetti, Frank Alexis, Eric M. Pridgen, and Omid C. Farokhzad).Part II Nanoparticles for Single Modality Molecular Imaging.5. Computed Tomography as a Tool for Anatomical and Molecular Imaging (Pingyu Liu, Hu Zhou, and Lei Xing).6. Carbon Nanotube X-Ray for Dynamic Micro-CT Imaging of Small Animal Models (Otto Zhou, Guohua Cao, Yueh Z. Lee, and Jianping Lu).7. Quantum Dots for In Vivo Molecular Imaging (Yun Xing).8. Biopolymer, Dendrimer and Liposome Nanoplatforms for Optical Molecular Imaging (David Pham, Ling Zhang, Bo Chen, and Ella F. Jones).9. Nanoplatforms for Raman Molecular Imaging in Biological Systems (Zhuang Liu).10. Single-Walled Carbon Nanotube Near-Infrared Fluorescent Sensors for Biological Systems (Jingqing Zhang, and Michael S. Strano).11. Microparticle- and Nanoparticle-Based Contrast-Enhanced Ultrasound Imaging (Nirupama Deshpande, and Jurgen K. Willmann).12. Ultrasound-Based Molecular Imaging Using Nanoagents (Srivalleesha Mallidi, Mohammad Mehrmohammadi, Kimberly Homan, Bo Wang, Min Qu, Timothy Larson, Konstantin Sokolov, and Stanislav Emelianov).13. MRI Contrast Agents Based on Inorganic Nanoparticles (Hyon B. Na, and Taghwan Hyeon).14. Cellular Magnetic Labeling with Iron Oxide Nanoparticles (Sebastien Boutry, Sophie Laurent, Luce V. Elst, and Robert N. Muller).15. Nanoparticles Containing Rare Earth Ions: A Tunable Tool for MRI (C. Riviére, S. Roux, R. Bazzi, J.-L. Bridot, C. Billotey, P. Perriat, and O. Tillement).16. Microfabricated Multispectral MRI Contrast Agents (Gary Zabow, and Alan Koretsky).17. Radiolabeled Nanoplatforms: Imaging Hot Bullets Hitting Their Targets (Raffaella Rossin).Part III: Nanoparticle Platforms as Multimodality Imaging and Therapy Agents.18. Lipoprotein-Based Nanoplatforms for Cancer Molecular Imaging (Ian R. Corbin, Kenneth Ng, and Gang Zheng).19. Protein Cages as Multimode Imaging Agents (Masaki Uchida, Lars Liepold, Peter Suci, Mark Young, and Trevor Douglas).20. Biomedical Applications of Single-Walled Carbon Nanotubes (Weibo Cai, Ting Gao, and Hao Hong).21. Multifunctional Nanoparticles for Multimodal Molecular Imaging (Yonglong Hou, and Rui Hao).22. Multifunctional Nanoparticles for Cancer Theragnostics (Seulki Lee, Ick Chan Kwon, and Kwangmeyung Kim).23. Nanoparticles for Combined Cancer Imaging and Therapy (Vaishali Bagolkot, Mikyung Yu, and Sangyong Jon).24. Multimodal Imaging and Therapy with Magnetofluorescent Nanoparticles (Jason McCarthy, and Ralph Weissleder).25. Gold Nanocages: A Multifunctional Platform for Molecular Optical Imaging and Photothermal Treatment (Leslie Au, Claire M. Cobley, Jingyi Chen, and Younan Xia).26. Theranostic Applications of Gold Nanoparticles in Cancer (Parmeswaran Diagaradjane, Pranshu Mohindra, and Sunil Krishnan).27. Gold Nanorods as Theranostic Agents (Alexander Wei, Qingshan Wei, and Alexei P. Lenov).28. Theranostic Applications of Gold Core-Shell Structured Nanoparticles (Wei Lu, Marites Melancon, and Chun Li).29. Magnetic Nanoparticle Carrier for Targeted Drug Delivery: Perspective, Outlook and Design (R.D.K. Misra).30. Perfluorocarbon Nanoparticles: A Multidimensional Platform for Targeted Image-Guided Drug Delivery (Gregory M. Lanza, Shelton D. Caruthers, Anne H. Schmieder, Patrick M. Winter, Tillmann Cyrue, Samuel and A. Wickline).31. Radioimmunonanoparticles for Cancer Imaging and Therapy (Arutselvan Natarajan).Part IV: Translational Nanomedicine.32. Current Status and Future Prospects for Nanoparticle-Based Technology in Human Medicine (Nuria Sanvicens, Fatima Fernandez, J.-Pablo Salvador, and M.-Pilar Marco).Index.

“This comprehensive volume summarizes the opinions of those in the forefront of research and describes the latest developments by emphasizing fundamentals and initiating hands-on application.”  (Imaging & Microscopy, 1 March 2012)"This monumental work of more than 800 pages is dedicated to the visualization of cellular behavior and molecular processes in living organisms using nanotechnologies. The book is written in a clear manner by tens of experts in the field." (Optics & Photonics News, 2011) "This comprehensive volume summarizes the opinions of those in the forefront of research and describes the latest developments by emphasizing fundamentals and initiating hands-on application." (Global Print Monitor, 8 March 2011)