Proteins act as macromolecular machinery that mediate many diverse biological processes - the molecular mechanisms of this machinery has fascinated biologists for decades.
Xin Zhang, PhD, received his Doctorate from The California Institute of Technology and now works at The Scripps Research Institute
Introduction.- A Multistep Mechanism for Assembly of the SRP-SR Complex.- Dynamics of the Transient Intermediate during SRP-SR Association.- Multiple Conformational Switches Control Cotranslational Protein Targeting.- Sequential Checkpoints Govern Substrate Selection during Cotranslational Protein Targeting.