Multimodal Optical Diagnostics of Cancer

Valery V. Tuchin is a professor and chairman of Optics and Biophotonics at Saratov National Research State University. He is also the head of laboratory, Institute of Precision Mechanics and Control, Russian Academy of Sciences, and the supervisor of Interdisciplinary laboratory of Biophotonics at National Research Tomsk State University. Dr. Tuchin is the editor of the Handbook of Coherent-Domain Optical Methods: Biomedical Diagnostics, Environmental Monitoring, and Materials Science (Springer). His research interests include biophotonics, tissue optics, laser medicine, tissue optical clearing, and nanobiophotonics. He is a guest professor of Huazhong University of Science and Technology (HUST) and Tianjin Universities of China, and adjunct professor at University of Limerick and National University of Ireland, Galway. He is member and fellow of SPIE and OSA, and a member of the IEEE.Jürgen Popp studied chemistry at the Universitiesof Erlangen and Wuerzburg. After his PhD in Chemistry, he joined Yale University for postdoctoral work. Since 2002 he has held the chair for Physical Chemistry at the Friedrich-Schiller University, Jena. Furthermore, since 2006, he is the Scientific Director of the Leibniz Institute of Photonic Technology, Jena. His research interests are mainly concerned with biophotonics according to the needs of pathology, oncology, and infection/sepsis. He is a member and fellow of SAS and SPIE.Valery P. Zakharov is a Professor and Chair of the Laser and Biotechnical Systems Department, and Head of the Photonics Laboratory, at Samara National Research University. His research interests include: laser medicine, biophotonics, multimodal biomedical imaging, and application of fluorescence and Raman-techniques for biomedical diagnostics. He has been awarded Honored Science Worker of Russia and the Samara Award for Biophotonics innovations. He has published more than 350 publications in peer refereed journals.

• Introduction: Enhancing Detection and Early Cancer Recognition with Multimodal Optical Imaging and Spectral Analysis.- Malignant tissue optics.- Optical clearing of biological tissues: prospects of application for multimodal cancer diagnostics.- Multiparametric analysis of tumor using microscopic fluorescence imaging.- NIRS for brain cancer detection.- Exhaled air analysis using wideband wave number tuning range infrared laser photoacoustic spectroscopy.- Multispectral and multimodal fiber sensing in oncology.- Diagnostics of pigmented skin tumors based on laser-induced autofluorescence and diffuse reflectance spectroscopy.- Raman-based molecular imaging and analytics, Surface-enhanced Raman spectroscopy for cancer diagnostics, Raman/CARS/TPEF/SHG multimodal imaging as a pathological screening tool.- In vivo Multimodal Optical Biopsy of Skin Cancer.- Raman hyperspectroscopy and advanced statistics for cancer differentiation.- Intraoperative brain cancer detection with Label-Free Multimodal Optical Spectroscopy.- 3D confocal Raman and two-photon microscopy imaging of the skin.- Multimodal Optical Imaging for Cancer Detection.- Multidimentional and Multilevel Imaging: towards 3D histopathology.- Multimodal OCT for malignancy imaging.- Multimodal texture analysis of OCT tumor images.- Hyperspectral imaging and cancer detection.- Multimodal Deep Imaging using SORS and OCT: for precise cancer boundary detection.- FLIM imaging combined with MRI.- Terahertz spectroscopy of human brain tumor.