The four-volume set LNICST 532, 533, 534 and 535 constitutes the refereed proceedings of the 5th EAI International Conference on Multimedia Technology and Enhanced Learning, ICMTEL 2023, held in Leicester, UK, during April 28-29, 2023.The 121 papers presented in the proceedings set were carefully reviewed and selected from 285 submissions. They were organized in topical sections as follows: AI-based education and learning systems; medical and healthcare; computer vision and image processing; data mining and machine learning; workshop 1: AI-based data processing, intelligent control and their applications; workshop 2: intelligent application in education; and workshop 3: the control and data fusion for intelligent systems.