Multifunctional Hydrogels for Biomedical Applications

Ricardo A. Pires has a background in materials engineering. Currently, he is an Assistant Researcher at 3B’s (Biomaterials, Biodegradables and Biomimetics) Research Group at the University of Minho, Braga/Guimarães, Portugal, and the European Institute of Excellence on Tissue Engineering and Regenerative Medicine at the University of Minho. He is also a member of the Portuguese Government Associate Laboratory ICVS/3B’s. His research interests include supramolecular hydrogels, 3D disease models, pathological peptide/protein aggregation, and bionanomaterials.Iva Pashkuleva has a background in chemistry. Currently, she is a Principal Researcher at 3B’s (Biomaterials, Biodegradables and Biomimetics) Research Group at University of Minho, Braga/Guimarães, Portugal, and the European Institute of Excellence on Tissue Engineering and Regenerative Medicine at University of Minho. She is also a member of the Portuguese Government Associate Laboratory ICVS/3B’s. Her research interests include glycan supramolecular systems, self-assembly, and cell-surface interactions. Rui L. Reis is a world recognized expert in Tissue Engineering and Regenerative Medicine (TERM). He is the Director of 3B’s (Biomaterials, Biodegradables and Biomimetics) Research Group and Full Professor of Tissue Engineering, Regenerative Medicine and Stem Cells at the University of Minho, Braga/Guimarães, Portugal. He is the CEO of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine and Director of the Portuguese Government Associate Laboratory ICVS/3B’s. He is well known for his pioneer works on the use of natural polymers for TERM.

• Preface xiii1 Extracellular Matrix Hydrogels from Decellularized Tissues for Biological and Biomedical Applications 1Brendan C. Jones, Nicola Elvassore, Paolo De Coppi, and Giovanni G. Giobbe1.1 Introduction to Hydrogels 11.2 Key Features and Functions of the Extracellular Matrix in Homeostasis and Development 61.3 Extracellular Matrix-Based Hydrogels Derived from Decellularization of Organs 81.4 Commercially Available Products 182 Collagen-Based Systems to Mimic the Extracellular Environment 23Umber Cheema and Vivek Mudera2.1 Cells in Tissues 232.2 Collagen in Tissues 242.3 Controlling Collagen Architecture 262.4 Engineering Collagen Scaffolds 292.5 Conclusions 333 Designing Elastin-Like Recombinamers for Therapeutic and Regenerative Purposes 37José Carlos Rodríguez-Cabello, Sara Escalera, Diana Juanes-Gusano, Mercedes Santos, and Alessandra Girotti3.1 Introduction 373.2 ELR-Based Hydrogels in Tissue Engineering 393.3 ELR-Based Hydrogels for Drug Delivery 483.4 Future Remarks 564 Enzyme-Assisted Hydrogel Formation for Tissue Engineering Applications 63Sílvia Pérez-Rafael, Eva Ramon, and Tzanko Tzanov4.1 Introduction 634.2 Enzymatically Cross-Linked Hydrogels 664.3 Supramolecular Enzyme-Driven Hydrogelation 754.4 Conclusions 815 Hierarchical Peptide- and Protein-Based Biomaterials: From Molecular Structure to Directed Self-assembly and Applications 97Yinchen Yuan, Yejiao Shi, and Helena S. Azevedo5.1 Introduction 975.2 Molecular Design/Selection of Building Blocks for Hierarchical Self-assembly 985.3 Hierarchical Assembly Through Environmental Manipulation 1085.4 Techniques for the Characterization of Hierarchically Organized Biomaterials 1135.5 Application of Hierarchical Self-assembling Peptide- and Protein-Based Biomaterials in Tissue Regeneration 1175.6 Conclusions 1206 Short Peptide Hydrogels for Biomedical Applications 127Priyadarshi Chakraborty, Lihi Adler-Abramovich, and Ehud Gazit6.1 Introduction 1276.2 Short Peptide Hydrogels 1286.3 Biomedical Applications of Short Peptide Hydrogels 1296.4 Conclusions and Outlook 1397 Supramolecular Assemblies of Glycopeptides as Mimics of the Extracellular Matrix 149Diana Soares da Costa, Alexandra Brito, Rui L. Reis, and Iva Pashkuleva7.1 Introduction 1497.2 Glycoproteins and Proteoglycans in the ECM 1507.3 Design of Self-assembling Peptide--Saccharide Conjugates 1517.4 Supramolecular Systems Generated by Interfacial Co-assembly 1547.5 Conclusions 1558 Supramolecular Assemblies for Cancer Diagnosis and Treatment 161Shuang Liu and Bing Xu8.1 Introduction 1618.2 Cancer Diagnosis 1628.3 Cancer Treatment 1738.4 Future Perspectives 1899 Polyzwitterionic Hydrogels as Wound Dressing Materials 195Konstans Ruseva and Elena Vassileva9.1 Polyzwitterions 1959.2 Wound Management and Wound Dressings 1979.3 PZIs as Dressings Materials for AcuteWounds 1989.4 PZI as Dressings for Chronic Wounds Management 2069.5 Conclusions 21210 Hyaluronan-Based Hydrogels as Modulators of Cellular Behavior 217Sara Amorim, Rui L. Reis, and Ricardo A. Pires10.1 Introduction 21710.2 Biological Relevance of Hyaluronan 21810.3 Hyaluronan-Based Systems for Biomedical Applications 22010.4 Conclusion and Future Remarks 22611 Hydrogel Fibers Produced via Microfluidics 233Kongchang Wei, Claudio Toncelli, René M. Rossi, and Luciano F. Boesel11.1 Introduction to Microfluidics and Microfluidic Wet Spinning 23311.2 Fabrication of Chips for Microfluidic Wet Spinning 23711.3 Biomedical Applications of Hydrogel Fibers Produced via Microfluidics 24211.4 Hydrogel Optical Fibers 25711.5 Conclusions 26312 Embedding Hydrogels into Microfluidic Chips: Vascular Transport Analyses and Drug Delivery Optimization 275Ana M. Martins, Alexander B. Cook, Martina Di Francesco, Maria Grazia Barbato, Sayanti Brahmachari, Martina Pannuzzo, and Paolo Decuzzi12.1 Introduction: Microfluidic Chips for Modeling Human Diseases and Developing New Therapies 27512.2 Hydrogels to Mimic the Extracellular Matrix (ECM) 27612.3 Fabrication of Microfluidic Chips 27712.4 Applications of Microfluidic Chips in Biophysical Transport Analysis 28212.5 Nanoparticle Transport Analyses 28412.6 Computer Simulations of Nanoparticle and Cell Transport 28512.7 Conclusions and Future Directions 28713 Multifunctional Granular Hydrogels for Tissue-Specific Repair 295Rui J. Almeida, Ana Fernandes, Vítor M. Gaspar, and João F. Mano13.1 Introduction 29513.2 Granular Hydrogels -- Functional Features and Design 29713.3 Granular Hydrogels for Tissue-Specific Repair 30813.4 Conclusions and Future Perspectives 31714 Injectable Hydrogels as a Stem Cell Delivery Platform for Wound Healing 323Qian Xu, Sigen A., and Wenxin Wang14.1 Wound Healing 32314.2 Stem Cells for Skin Wound Healing 32814.3 Injectable Hydrogel Dressing as a Delivery Platform 331Index 357