Multi-component Reactions in Molecular Diversity

Jean-Philippe Goddard is Professor of Molecular Chemistry at the University of Upper Alsace, France, and Deputy Director of LIMA (Laboratory of Molecular Innovation and Applications), Strasbourg, France.Max Malacria is Emeritus Professor at Sorbonne University, Paris, France, where he researches the fields of catalysis, radical chemistry and aromaticity.Cyril Ollivier is a CNRS Research Director at the IPCM (Parisian Institute of Molecular Chemistry) at Sorbonne University.

• Chapter 1. Organometallic Multicomponent Reactions 1Nuno MONTEIRO1.1. Introduction 11.2. Multicomponent reactions: concept and applications 21.2.1. Concept and correlation with the principles of green chemistry 21.2.2. Origins and areas of application 51.3. Merging multicomponent and organometallic transformations 91.3.1. History: the predominant role of palladium 91.3.2. Contribution of catalysis in multicomponent reactions 121.3.3. Multicomponent catalytic reactions: design and applications 241.4. Conclusion 481.5. References 49Chapter 2. Use of 1,3-Dicarbonyl Derivatives in Stereoselective Domino and Multicomponent Reactions 59Damien BONNE, Thierry CONSTANTIEUX, Yoann COQUEREL and Jean RODRIGUEZ2.1. Introduction 592.2. Domino reactions 612.2.1. Diastereoselective domino reactions 612.2.2. Enantioselective domino-domino reactions 692.3. Multicomponent reactions 812.3.1. Diastereoselective multicomponent reactions 812.3.2. Enantioselective multicomponent reactions 922.4. Conclusion 1042.5. References 105Chapter 3. Multicomponent Radical Processes: Recent Developments 121Yannick LANDAIS3.1. Polar effects: electrophilic and nucleophilic radical scales 1223.2. Multicomponent radical reactions 1233.2.1. Three-component radical reactions: radical additions to olefins 1233.2.2. Three-component radical reactions: radical additions on imines 1353.2.3. Four- and five-component radical reactions: carbonylation reactions 1403.3. Multi-component radical-ionic reactions 1453.3.1. Multi-component radical-anionic reactions 1453.3.2. Multi-component radical-cationic reactions 1573.4. Sequential multicomponent radical reactions 1603.4.1. Organometallic-radical sequential reactions 1603.4.2. Ugi reactions: radical reactions 1613.4.3. Passerini reaction using radicals 1633.5. Multicomponent reactions by photoredox catalysis 1663.6. Conclusion 1723.7. References 172List of Authors 183Index 185