Mucins

After completing studies for the A.B., A.M., and Ph.D. degrees in chemistry at Harvard University, David W. Christianson joined the faculty of the University of Pennsylvania, where he is currently the Roy and Diana Vagelos Professor in Chemistry and Chemical Biology. At Penn, Christianson’s research focuses on the structural and chemical biology of the zinc-dependent histone deacetylases as well as enzymes of terpene biosynthesis. His research accomplishments have been recognized by several awards, including the Pfizer Award in Enzyme Chemistry and the Repligen Award in Chemistry of Biological Processes from the American Chemical Society, a Guggenheim Fellowship, and the Elizabeth S. and Richard M. Cashin Fellowship from the Radcliffe Institute for Advanced Study at Harvard University. Christianson is also a dedicated classroom teacher, and his accomplishments in this regard have been recognized by the Lindback Award for Distinguished Teaching at Penn and a Rhodes Trust Inspirational Educator Award from Oxford University. Christianson has also held visiting professorships in the Department of Biochemistry at Cambridge University and the Department of Chemistry and Chemical Biology at Harvard University. Christianson has served with Prof. Anna Pyle as Co-Editor-in-Chief of Methods in Enzymology since 2015.Dr. Karen N. Allen works at the Department of Chemistry of the Boston University, the Metcalf Center for Science and Engineering

• 1. Enrichment/isolation, glycoproteomicsStacy Malaker, Shane Finn and Sarah Lowery2. Mucinase cleavage characterization and usage in glycoproteomicsStacy Malaker, Alexandra Steigmeyer and Joann Chongsaritsinsuk3. Fluorescent protein-based FRET substrates for activity screening of mucinasesAlisdair Boraston4. Development of clinical lectin assays based on MS glycomic discoveryNiclas Karlsson, Ali Reza Afshari and Mary Solbego5. Enzymatic selective sulfation of synthetic mucinsJessica Kramer6. cryoEMDeborah Fass7. Cell-based mucin arrays and glycoengineeringYoshiki Narimatsu, Christian Bull, Henrik Clausen and Felix Goerdeler8. CRISPR screens to characterize and identify glycan-binding proteinsSimon Wisnovsky9. MD SimulationsFiona Kearns10. Interactions with pathogenic bacteriaKatharina Ribbeck11. Interactions with microbiotaEric Martens12. Covalent crosslinking of mucinsThomas Crouzier13. Liquid Glycan and Liquid Lectin Array-based exploration of musin recognitionRatmir Derda14. Quantification of mucinsSumaira Z. Hasnain15. Mucins in IBDKirk Bergstrom16. Investigatins mucins and innate immunityThaher Pelaseyed17. Generating synthetic mucin glycopeptidesPeter Seeberger, Kabita Pradhan and Charlotte Völkel18. Microscopy and imagingMalin E.V. Johansson, George M H Birchenough, Elisabeth E L Nyström and Brendan Dolan