Del 1157 i serien Advances in Experimental Medicine and Biology

mRNA Metabolism in Human Disease

Häftad, Engelska, 2020

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The eukaryotic gene expression pathway involves a number of interlinked steps, with messenger RNA (mRNA) being the key intermediate. Although eukaryotic cells have evolved elaborate mRNA quality control mechanisms that ensure the fidelity of gene expression, some defects are not detected, thus affecting mRNA metabolism.

Produktinformation

Utgivningsdatum2020-08-15
Mått178 x 254 x 11 mm
Vikt422 g
FormatHäftad
SpråkEngelska
SerieAdvances in Experimental Medicine and Biology
Antal sidor180
FörlagSpringer Nature Switzerland AG
ISBN9783030199685

Tillhör följande kategorier

Medicinsk genetik inom Medicin
Onkologi inom Medicin
Maskinteknik och material inom Naturvetenskap och teknik
Medicinsk utrustning och medicinska tekniker inom Medicin

Prelims.- Networks of mRNA processing and alternative splicing regulation in health and disease.- The diverse roles of RNA-binding proteins in glioma development.- Nonsense-mediated mRNA decay in development, stress and cancer.- Implication of mRNA degradation disorders on human DISease: focus on DIS3 and DIS3-like enzymes.- Translational regulation by upstream open reading frames and human diseases.- Alternative mechanisms of mRNA translation initiation in cellular stress response and cancer.- RNA therapeutics: how far have we gone? Index.