Molecular Modeling and Dynamics of Bioinorganic Systems

Häftad, Engelska, 1997

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In the modelling of biological molecules containing metal ions, new approaches and techniques are allowing researchers to discuss structures, electronic properties and reaction mechanisms of metalloproteins on the basis of computational studies. Offering a selection of papers on recent progress in this field, this book discusses different approaches in the development of new force fields and their application to the computation of the structures, electronic properties and dynamics of bioinorganic compounds, as well as quantum mechanical and integrated QM/MM methods for understanding the function of metalloenzymes and the calculation of electrostatic interactions.

Produktinformation

Utgivningsdatum1997-11-30
Mått160 x 240 x 27 mm
Vikt772 g
FormatHäftad
SpråkEngelska
SerieNATO Science Partnership Subseries: 3
Antal sidor470
Upplaga1997
FörlagKluwer Academic Publishers
ISBN9780792348245

Tillhör följande kategorier

Biologi inom Naturvetenskap och teknik
Biokemi inom Naturvetenskap och teknik
Fysikalisk kemi inom Naturvetenskap och teknik
Oorganisk kemi inom Naturvetenskap och teknik

1 Solution Structures of Proteins Containing Paramagnetic Metal Ions.- 2 Modeling of Structures and Molecular Properties of Transition Metal Compounds — Toward Metalloprotein Modeling.- 3 Extending Molecular Mechanics Methods to the Descriptions of Transition Metal Complexes and Bond-Making and -Breaking Processes.- 4 A Novel Molecular Mechanics Strategy for Transition Metals Bound to Biological Molecules.- 5 Computational Analysis of Inorganic and Bio-Inorganic Nickel Complexes.- 6 Molecular Modeling of Platinum Complexes with Oligonucleotides: Methodological Lessons and Structural Insights.- 7 Metal Cations in Biological Systems: Modeling Metal Ions in lonophores and DNA.- 8 The Role of Ca2+ in the Binding of Carbohydrates to C-Type Lectins as Revealed by Molecular Mechanics and Molecular Dynamics Calculations.- 9 Molecular Dynamics Calculations on Metalloproteins.- 10 The Effective Crystal Field Methodolgy as Used to Incorporate Transition Metals Into Molecular Mechanics.- 11 Quantum Chemical Studies of Transition Metal Catalyzed Enzyme Reactions.- 12 Ab Initio and Desity Functional Theory Applied to Models for the Oxo Transfer Reaction of Dioxomolybdenum Enzymes.- 13 Quantum Mechanical Modeling of Active Sites in Metalloproteins. Electrostatic Coupling to the Protein/Solvent Environment.- 14 Semi-empirical MO Calculations on Enzyme Reaction Mechanisms.- 15 Normal Mode Analysis of Proteins to Interpret Resonant and Inelastic Scattering of ? Quanta.- 16 Computer Simulations of the Action of Metalloenzymes.- 17 The Role of the Protein in Modulating Cofactor Electrochemistry in Proteins: The Calculation of Electrostatic Forces.- 18 Molecular Dynamics Study of H93G Sperm Whale Deoxymyoglobin Mutants with Exogenous Proximal Ligands.- 19 The Role of Electrostatics atthe Catalytic Metal Binding Site in Xylose Isomerase Action.- 20 Copper(II) and Zinc(lI) Complexes of Peptides as Models for Collagenase Inhibitors.