Molecular Mechanisms of Werner’s Syndrome

Häftad, Engelska, 2012

AvMichel Lebel

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To some, Werner's syndrome is considered a caricature of aging, but others will find it fascinating that only one mutated human gene (WRN) can bring about a multitude of complicated phenotypes that are usually associated with aging.

Produktinformation

Utgivningsdatum2012-11-06
Mått156 x 234 x 10 mm
Vikt266 g
FormatHäftad
SpråkEngelska
Antal sidor156
FörlagSpringer-Verlag New York Inc.
ISBN9781461347668

Tillhör följande kategorier

Geriatrik inom Medicin
Biologi inom Naturvetenskap och teknik
Biovetenskap inom Naturvetenskap och teknik
Cellbiologi inom Naturvetenskap och teknik

1. Clinical Aspects of Werner’s Syndrome: Its Natural History and the Genetics of the Disease.- 2. Biochemical Roles of RecQ Helicases.- 3. Biochemical Characterization of the Werner Syndrome DNA Helicase-Exonuclease.- 4. Proteins That Interact with the Werner Syndrome Gene Product.- 5. Sensitivity of Werner’s Syndrome Cells to DNA Damaging Agents: Insights into the Biological Functions of the Werner Protein.- 6. Yeast RecQHelicases: Clues to DNA Repair, Genome Stability and Aging.- 7. Potential Function of the Werner’s Syndrome Homologue in the African Clawed Frog and the Mouse.- 8. Proposed Biological Functions for the Werner Syndrome Protein in DNA Metabolism.- Replicative Senescence, Telomeres and Werner’s Syndrome.