Molecular Mechanisms in Hypertension

• Part I: Renin / Angiotnsin /Aldosterone Systems. Biology of AII (Synthesis, Degradation, Measurement, Fragments and A1-7, AIV, ACE2, Inflammation, Coagulation, Angiogenesis). Actions of AII. Actions of Aldsterone. Biology of Renin/Prorenin/Renin Exon 1A/Direct Renin Action, Renin Synthesis. Circulating RAAS. Tissue RAASs Part II: Renal Mechanisms in Hypertension. Pressure Naturesis. Intraglomerular Pressure and Nephron Loss . Nephron Number and BP. Renal Prostaglandins/Depressors and BP. Role of Dopamine. Modulator and Non-Modulator Hypertension. TGF and BP. Renal Causes of Secondary Hypertension. ACE Inhibitor Prevention of Hypertension. Other Mechanisms Part III: Endocrine Hypertension. Adrenocortical Hypertension. Adrenergic Nervous System. Pheochromocytoma. Other Endocrine Causes of Hypertension Part IV: Non-Ras Peptides. Vasopressin and Neuropeptide Y, Calcitonin GRP, Leptin. Natriuretic Factors. Endothelin. Kinins/ACE Substrates Part V: Secondary Messengers and the Sequelae of Hypertension. Signal Transduction. Regulation of Blood Flow (incl TGF). Vascular Distensability, Pulse Pressure, and Vascular Pathology. Myogenic Regulation and BP. Regression of Vascular Hypertrophy. Left Ventricular Hypertrophy Onset/Regression/Remodeling/Fibrosis. Nitric Oxide/Oxidative Stress/Endothelial (Dys)Function. Prostaglandins, Lypoxigenase Products and BP Control. Endogenous Na/K ATPase Inhibitors Part VI: Genomics, Proteomics and Hypertension. Gene Regulation, Hypertension, Hypertensive Sequelae. Genomic Microarrays and Hypertension. Transgenic and Knock-Out Models of Hypertension. Application of Antisense and Sirna to the Study of Hypertension. Heritable Monogenic Forms of Hypertension (Liddle's etc, Laidlaw's etc) 39. Genetics of Hypertension. Gene Therapy and Hypertension. Proteomics and Hypertension. The Proteosome and the Development of Hypertensive Sequelae. Apoptosis and the Sequelae of Hypertension 44. Stem Cells and Cardiovascular Structure Part VII: Other Issues. Sodium and Potassium in Hypertension. Divalent Cations/ Hypertension. Birthweight and Hypertension. Baroreflexes

"…this text throws down the gauntlet and compels physicians to not simply be content with prescribing the medications currently available, but instead to look to locate the catalyst behind the breakdown in hopes that a better understanding of the disease will inspire more efficient medical therapies (and eventual prevention)."-Electric Review