Molecular Mechanisms Determining Mammalian Oocyte Quality

Oocyte Developmental Competence, Aneuploidy, and Clinical Relevance

Häftad, Engelska, 2024

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Shortly before birth, the oocyte undergoes a prolonged arrest at prophase I until the age of puberty, at which selected oocytes resume meiosis I.

Produktinformation

Utgivningsdatum2024-07-20
Mått155 x 235 x 8 mm
Vikt224 g
FormatHäftad
SpråkEngelska
SerieAdvances in Anatomy, Embryology and Cell Biology
Antal sidor129
FörlagSpringer International Publishing AG
ISBN9783031551628

Tillhör följande kategorier

Cellbiologi inom Naturvetenskap och teknik
Reproduktionsmedicin inom Medicin
Biovetenskap inom Naturvetenskap och teknik

Dr. Ahmed Balboula is an Assistant Professor in the Division of Animal Sciences at the University of Missouri. The research in Dr. Balboula’s laboratory focuses on understanding molecular mechanisms regulating oocyte meiosis and early embryonic development. This research is crucial for preventing the development of aneuploid gametes that can result in miscarriage or developmental disorders as well as protecting against infertility in humans and animals. Dr. Balboula employs cutting-edge methodologies in his laboratory, including the use of transgenic mouse models, genetic constructs, laser ablation, and advanced imaging technologies. This multidisciplinary approach allows for a comprehensive understanding of reproductive and cell biology, offering valuable contributions to the field.

Chapter 1. Predicting Infertility: How Genetic Variants in Oocyte Spindle Genes Affect Egg Quality.- Chapter 2. Regulation of Oocyte mRNA Metabolism: A Key Determinant of Oocyte Developmental Competence.- Chapter 3. Mechanisms of DNA Damage Response in Mammalian Oocytes.- Chapter 4. How do Environmental Toxicants Affect Oocyte Maturation via Oxidative Stress?.- Chapter 5. Molecular Mechanisms Determining Mammalian Oocyte Quality with the Treatment of Cancer Therapy.- Chapter 6. Telomere Elongation during Pre-implantation Embryo Development.