Molecular Genetics of Endometrial Carcinoma

Dr. Lora Hedrick Ellenson is Professor of Pathology and Laboratory Medicine and Director of the Division of Gynecological Pathology at Weill Cornell Medicine. She has a national reputation for her expertise in endometrial carcinoma. Dr. Ellenson’s research interest is primarily focused on the molecular genetics and pathology of endometrial carcinoma, the most common malignancy of the female genital tract. In addition to satisfying her clinical duties, Dr. Ellenson oversees an NIH funded research program to develop genetic mouse models of endometrial tumorigenesis in addition to defining the differences, and similarities, in the molecular genetic alterations in the two major types of endometrial carcinoma. She has over 80 publications on the topic with over 3,430 citations.

• Part 1. Introduction.- 1. Epidemiology and metabolic/hormonal influences.- 2. Pathology.- 3. Clinical behavior and treatment.- Part 2. Molecular Profiling.- 4. Traditional approaches.- 5. Next generation sequencing.- 6. Specific Pathways.- Part 3. Mouse models.- 7. Pten.- 8. Mig-6.- 9. Lkb.- Part 4. 10. Future Directions.- Index.