Molecular Chaperones in Human Disorders

Inbunden, Engelska, 2019

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Molecular Chaperones in Human Disorders, Volume 114 in the Advances in Protein Chemistry and Structural Biology series, provides an overview of current developments in mechanisms underlying DNA repair and their involvement in maintaining chromatin repair, the balance between chromosomal repair pathways, tumorigenesis, immune signaling and infection-induced inflammation. Chapters in this new release cover Functional principles and regulation of molecular chaperones, Chaperones and retinal disorders, Protein misfolding and degradation in genetic diseases, Chaperone dysfunction in hereditary myopathic diseases, Diseases caused by functional disorder of molecular chaperones residing in the endoplasmic reticulum, and many other timely topics.

Describes advances in our understanding on DNA repair mechanisms and the involvement of their dysregulation in promoting diseases
Provides an ideal resource for a very wide audience of specialists, researchers and students
Contains timely chapters written by well-renown authorities in their field
Presents information that is well supported by a number of high quality illustrations, figures and tables

Produktinformation

Utgivningsdatum2019-01-09
Mått152 x 229 x 31 mm
Vikt810 g
FormatInbunden
SpråkEngelska
SerieAdvances in Protein Chemistry and Structural Biology
Antal sidor423
FörlagElsevier Science
MedarbetareRossen Donev
ISBN9780128155578

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Rossen Donev received his PhD degree in 1999 from the Institute of Molecular Biology, Bulgarian Academy of Sciences. He did postdoctoral training at Imperial Cancer Research Fund, UK (renamed after the merger with Cancer Research Campaign to Cancer Research UK, London Research Institute) and Cardiff University. In 2007 he was awarded a New Investigator Grant Award from the Medical Research Council (UK) to establish himself as an independent Principle Investigator. In 2010 Dr. Donev was appointed Senior Lecturer at Swansea University. In 2016 Dr. Donev joined MicroPharm Ltd (UK) where currently he is Head of Research. He has published more than 60 research papers, chaired scientific meetings and given invited plenary talks. Rossen Donev has consulted on projects related to development of treatments for neurodevelopmental disorders and cancer therapies. He serves as Editor-in-Chief of the Advances in Protein Chemistry and Structural Biology and on editorial board of several other journals. His research interests include signaling pathways involved in neuropsychiatric disorders and tumor escape from the immune system, and development of therapeutic strategies for their treatment. More recently he has focused on development of immunotherapeutics for non-systemic applications.

1. Functional principles and regulation of molecular chaperonesJohannes Buchner2. Chaperones and retinal disordersNikolai O. Artemyev3. Protein misfolding and degradation in genetic diseasesRasmus Hartmann-Petersen4. Chaperone dysfunction in hereditary myopathic diseasesAndreas Roos5. Diseases caused by functional disorder of molecular chaperones residing in the endoplasmic reticulumMasafumi Sakono6. Structural and functional insights on the roles of molecular chaperones in the mistargeting and aggregation phenotypes associated with primary hyperoxaluria type IAngel Luis Pey7. Inflammatory response and its relation to sphingolipid metabolism proteins: Targeting inflammation with molecular chaperonesElif Ozkirimli8. When safeguarding goes wrong: impact of oxidative stress on proteins homeostasis in health and neurodegenerative disordersDana Reichmann9. Computational approach to unravel the misfolding mechanism of Glucosylceramidase mutations in Gaucher DiseaseGeorge Priya Doss P. C10. Cytosolic quality control proteins, SGTA and the Bag6 complex, in diseaseRivka L. Isaacson