Molecular Biology of B-Cell and T-Cell Development

Häftad, Engelska, 2010

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This cutting-edge review of the current status of research on the early development of lymphocytes emphasizes molecular mechanisms controlling lineage commitment and selection. The reviews explore cellular and molecular aspects of the microenvironment in regulating lymphoid development, discuss ligands and receptors that mediate interactions between progenitor and cells comprising the stromal microenvironment, and demonstrate which are the triggering receptors, signaling pathways, and the developmental checkpoints controlling correct development of B- and T-cells. There is also a comparison of the vital roles of transcription factor combinations in establishing cell identity in the erythroid, myeloid, B, and T lineages. By juxtaposing the insights and approaches normally confined to either "immunology" or "hematology," this important book will help spark the growth of new research initiatives at the intersection of these two fields.

Produktinformation

Utgivningsdatum2010-11-09
Mått178 x 254 x 35 mm
Vikt1 110 g
FormatHäftad
SpråkEngelska
SerieContemporary Immunology
Antal sidor587
FörlagHumana Press Inc.
ISBN9781617370656

Tillhör följande kategorier

Onkologi inom Medicin
Biologi inom Naturvetenskap och teknik

I: Stem Cells and Lineage Commitment Models.- CH. 1. Developmental Origins of Hematopoietic Stem Cells.- CH. 2. Self-Renewal of Stem Cells: The Intrinsic Timetable Model.- CH. 3. Transcription Factors Regulating Early Hematopoietic Development and Lineage Commitment.- II: Intrinsic Factors Regulating B and T Lymphopoiesis.- CH. 4. The Ikaros Gene Family in Hemopoietic Differentiation.- CH. 5. Transcriptional Control of B-Cell Differentiation by EBF and E2A.- CH. 6. Role of the Transcription Factor BSAP (Pax-5) in B-Cell Development.- CH. 7. The Role of PU.1 in the Regulation of Lymphoid and Myeloid Hematopoietic Progenitors.- CH. 8. Chromatin Structure and Lineage Determination.- III: Extrinsic Factors Regulating B and T Lymphopoiesis.- CH. 9. The Role of Cytokines in Hematolymphoid Development.- CH. 10. Life/Death Decisions in B-Lymphocyte Precursors: A Role for Cytokines, Cell Interaction Molecules, and Hormones.- CH. 11. Regulation of Lymphocyte Development by Microenvironmental and Systemic Factors.- CH. 12. Cytokines and Chemokines in 1-Cell Development.- CH. 13. Cytokine and Stromal Influences on Early B-Cell Development.- IV: Commitment and Ordered Progression in Development of Lymphoid Lineages.- CH. 14. Staging B-Cell Development and the Role of Ig Gene Arrangement in B-Lineage Progression.- CH. 15. Lineage Relationships Between B Lymphocytes and Macrophages.- CH. 16. TCR-Independent Development of Pluripotent 1-Cell Precursors.- CH. 17. T-Cell Development from Hematopoietic Stem Cells.- CH. 18. Gene Regulation in T-Cell Lineage Committment.- CH. 19. The ??/?? Lineage Decision: An Evaluation of the “T-Cell Receptor Determinant,” “Progenitor Precommitment,” or “Codeterminant” Models.- V: Selection Processes Operating During B-LymphocyteDevelopment.- CH. 20. Structure and Function of the Pro- and Pre-B-Cell Receptors on B-Lymphoid Lineage Precursor Cells.- CH. 21. Molecular Mechanisms Regulating Negative Selection in Immature-Stage B-Cells.- VI: Selection Processes Operating During T-Lymphocyte Development.- CH.22. How Essential Is the Pre-T Cell Receptor?.- CH.23. Developmental Stage-Specific Responses to Ligation of CD3-Containing Complexes.- CH.24. The Molecular Basis of Thymocyte Positive Selection and CD4/CD8 Lineage Commitment.- VII: Clinical Applications of Hematolymphoid Development.- CH. 25. Stem Cell Transplants for Hematopoietic Malignancies.- CH. 26. Placental Blood: Immunology, Transplantation, and Gene Therapy.- CH. 27. Human Hematopoietic Stem Cells, Progenitors, and Peripheral Blood Lymphocytes as Targets for the Correction of Immune System Disorders via Gene Therapy.

"... can be unequivocally recommended to people involved in the study of lymphocytes and lymphoma research."-Annals of Oncology "...This volume presents an integrated and comprehensive account of cutting edge advances in understanding B and T lymphocyte development, and a deeper understanding of the actual cellular and molecular processes that control cell fates...this important new book will help spark the growth of new research initiatives at the intersection of these two fields, claiming center ground as essential reading in the field."-Anticancer Research