Molecular Basis of Human Cancer

William B. ColemanDepartment of Pathology and Laboratory medicine, Curriculum in Toxicology, Program in Translational Medicine, UNC Lineberger Comprehensive Center, University of North Carolina School of Medicine, Chapel Hill, NC

• Cancer Epidemiology: Incidence and Etiology of Human Neoplasms.- Essential Concepts and Techniques in Molecular Biology.- Cancer Genomics.- Cancer Cytogenetics.- The Epigenetic Basis of Human Cancer.- Cancer Proteomics.- An Overview of Cancer Genes.- Oncogenes and the Initiation and Maintenance of Tumorigenesis.- Positive Mediators of Cell Proliferation in Neoplasia: Growth Factors and Receptors.- Senescence, Apoptosis, and Cancer.- Novel Cancer Therapies Targeting Angiogenesis.- Beyond the Primary Tumor: Progression, Invasion, and Metastasis.- Simple Sequence Mutations.- Single Nucleotide Polymorphisms and Cancer Susceptibility.- Chromosomes and Chromosomal Instability in Human Cancer.- Epigenetic Mechanisms in Cancer Development.- MicroRNAs and Cancer.- Erionite and Asbestos in the Pathogenesis of Human Malignant Mesotheliomas.- Viral Mechanisms in Human Carcinogenesis.- Hormonal Carcinogenesis: The Role of Estrogens.- Sporadic Cancers.- Hereditary Cancer.- Retinoblastoma:  Clinical and Molecular Perspectives.- Xeroderma Pigmentosum and the DNA Damage Response to Ultraviolet Light.- Hereditary Colorectal Cancer.- Hereditary Breast and Ovarian Cancer.- The Molecular Basis of Prostate Carcinogenesis.- Molecular Basis of Lung Carcinogenesis.- The Molecular Basis of Skin Carcinogenesis.- The Molecular Biology of Leukemias.- Molecular Mechanisms in Non-Hodgkin Lymphoma.- The Molecular Pathology of Head and Neck Squamous Cell Carcinoma.- Ovarian Cancer.- Molecular Pathology of Bone and Soft Tissue Tumors.- The Molecular Biology of Human Brain Tumors.- Cancer Drug Discovery and Anticancer Drug Development.- Biological Principles and Clinical Application of EGFR Inhibitors in Cancer.- Targeting Oncoproteins for Molecular Cancer Therapy.- Therapeutic Agents that Inhibit Angiogenesis.- Small Molecule Inhibitors.- Molecular Detection and Diagnosis of Cancer.- Gene Therapy in the Treatment of Human Cancer.- Personalized Medicine for the Treatment of Human Cancer.