Molecular Aspects of Neurodegeneration, Neuroprotection, and Regeneration in Neurological Disorders

Akhlaq A. Farooqui is a leader in the field of signal transduction processes, lipid mediators, phospholipases, glutamate neurotoxicity, and neurological disorders. He is a research scientist in the Department of Molecular and Cellular Biochemistry at The Ohio State University. He has published cutting edge research on the role of phospholipases A2 in signal transduction processes, generation and identification of lipid mediators during neurodegeneration by lipidomics. He has studied the involvement of glycerophospholipid, sphingolipid-, and cholesterol-derived lipid mediators in kainic acid neurotoxicity, an experimental model of neurodegenerative diseases. Akhlaq A. Farooqui has discovered the stimulation of plasmalogen- selective phospholipase A2 in brains of patients with Alzheimer disease (AD). Stimulation of this enzyme may not only be responsible for the deficiency of plasmalogens in neural membranes of AD patients, but also be related to the loss of synapse in the AD.

• 1. Molecular aspects of neurodegeneration and classification of neurological disorders2. Effect of diet on neurological disorders and regenerative processes in the brain3. Molecular mechanisms of neurodegeneration in neurotraumatic diseases4. Molecular mechanisms of neurodegeneration in neurodegenerative diseases 5. Molecular mechanisms of neurodegeneration in neuropsychiatric diseases6. Molecular aspects of regeneration and neuroprotection in neurotraumatic diseases7. Molecular aspects of regeneration and neuroprotection in neurodegenerative diseases 8. Molecular aspects of regeneration and neuroprotection in neuropsychiatric diseases9. Strategies for the potential treatment of neurological disorders with Chinese and Indian medicinal plants10. Summary, perspective, and future studies on neurodegeneration and regeneration in neurological disorders

"I believe this to be a very worthy text that will be used by both researchers and clinicians with different goals. I can also see a role for those studying nutrition and the microbiome. I do not believe there is a text that takes a similar level of detail into the molecular considerations of not only neurodegeneration, but the implications for neuroprotection and regeneration with highlights on the many specific clinical conditions." --Doody