Molecular Aspects of Alcohol and Nutrition

A Volume in the Molecular Nutrition Series

Inbunden, Engelska, 2015

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Molecular Aspects of Alcohol and Nutrition is a valuable resource for nutrition researchers and nutritionists who study or treat alcohol-related diseases. Experts from across the field of alcohol research explain how alcohol disrupts normal fat, carbohydrate, and protein metabolic processes occurring in the liver as well as other parts of the body.

The book discusses how this can lead to alcoholic liver disease (ALD) as well as contribute to the onset of Type 2 diabetes and the metabolic syndrome. It also explores how alcohol affects nutrient absorption in the gastrointestinal tract and can lead to anemia and reduced amounts of fat soluble vitamins.

This book explores both the primary and secondary consequences of alcohol consumption. Chapters in the first section investigate the basic science of alcohol metabolism - focusing on how alcohol and its toxic metabolites disrupt and impair normal nutrient regulation at the molecular level. Further chapters explore how alcohol affects many extra-hepatic organs and tissues as well as the secondary consequences of alcohol consumption such as reduced levels of minerals like magnesium, calcium, and trace elements like zinc.

Offers a valuable resource for nutrition researchers and nutritionists who study alcohol-related diseases and attempt to treat them through nutritional strategies
Explores how alcohol and its toxic metabolite acetaldehyde disrupt and impair normal macro and micro nutrient regulation at the molecular level
Investigates how alcohol affects and interferes with cell signaling, cell death pathways, calcium homeostasis leading to osteoporosis, oxygen balance, as well as the pathophysiology of alcohol consumption and abuse

Produktinformation

Utgivningsdatum2015-11-11
Mått216 x 276 x 21 mm
Vikt1 310 g
FormatInbunden
SpråkEngelska
Antal sidor400
FörlagElsevier Science
ISBN9780128007730

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Dr. Patel is a Reader at the University of Westminster. After completing his PhD at King’s College London, he continued his research experience by undertaking his post-doctoral studies in the laboratory of Professor Cunningham in the Department of Biochemistry at the Wake Forest University School of Medicine, (Winston-Salem, NC, USA). This extensive project involved investigating mechanisms of hepatic mitochondrial ribosome dysfunction in alcoholic liver disease (ALD) using biophysical and proteomic techniques. These studies have led to new avenues in determining the pathology of ALD. His teaching areas at both post-graduate and undergraduate levels include clinical biochemistry, investigative pathology and laboratory investigation.

Section 1. General and Introductory Aspects1. Nutrients and Liver Energy MetabolismDaniel Gyamfi and Kwabena Owusu Danquah 2. Alcohol Metabolism: general aspectsReem Ghazali and Vinood B. PatelSection 2. Molecular biology of the cell3. Alcohol and aldehyde dehydrogenases: molecular aspectsKwabena Owusu Danquah4. Apoptosis and alcohol F.A. Middleton5. Pathogenic Mechanisms in Alcoholic Liver Disease (ALD): emerging role of Osteopontin Wing-Kin Syn and Jason D. Coombes 6. The Role of CD36 in the Pathogenesis of Alcohol-Related DiseaseCaleb T. Epps, Robin D. Clugston, Amit Saha, William S. Blaner and Li-Shin Huang 7. Thiamine deficiency in alcoholicsAnn M. Manzardo8. Vitamin B regulation of Alcoholic Liver DiseaseCharles H. Halsted and Valentina Medici 9. Vitamin D and alcohol interactions and implication for boneEmilio Gonzalez-Reimers, Geraldine Quintero-Platt, Antonio Martinez-Riera and Francisco Santolaria-Fernandez 10. Antioxidant treatment of alcoholismCamila Siqueira Silva, Helio Vannucchi and Guilherme Vannucchi Portari 11. Selenium dietary supplementation and oxidative balance in alcoholismOlimpia Carreras, María Luisa Ojeda and Fatima Nogales 12. Role of zinc in alcoholic liver diseaseZhanxiang Zhou13. Interactions between alcohol and folateBogdan Cylwik14. Effects of Acetladehyde on intestinal barrier functionD. Jonkers and Elhaseen Elamin 15. Cholesterol regulation by leptin in alcoholic liver diseaseBalasubramaniyan Vairappan16. CRF system and alcohol consumptionAndrey E. Ryabinin and William J. Giardino 17. Metabolic profiling approaches for biomarkers of ethanol intakeHelen G. Gika and Ian D. Wilson Section 3. Genetic machinery and its function18. Gene expression in alcoholism: an overviewReem Ghazali and Vinood B. Patel 19. Cytochrome P4502E1 Gene Polymorphisms in alcoholicsTao Zeng and K.-Q. Xie 20. Genes associated with alcohol withdrawal Kesheng Wang and Liang Wang 21. Alcohol and epigenetic modulations Claudio D'Addario and Mauro Maccarrone 22. miRNA Expression in the alcoholic liver diseaseShashi Bala22. Alcohol and DNA MethylationFeng C. Zhou24. Ethanol-mediated carcinogenesis molecular insights as an overviewHelmut K. Seitz25. Molecular link between alcohol and breast cancer: the role of salsolinolMariko Murata, Kaoru Midorikawa and Shosuke Kawanishi 26. Ethanol impairs Phospholipase D signaling in astrocytesUte Burkhardt and Jochen Klein 27. Metabolite changes in alcohol gonadotoxicityGanna M. Shayakhmetova and Larysa B. Bondarenko 28. Hepcidin and iron dysregulation in alcoholicsKosha Mehta and Vinood B. Patel