Molecular and Cellular Mechanobiology

Häftad, Engelska, 2018

AvShu Chien,Adam J. Engler,Peter Yingxiao Wang

2 469 kr

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This book will cover the cutting-edge developments in molecular and cellular mechanobiology to date. An integrative approach across different scales from molecular sensing to mechanotransduction and gene modulation for physiological regulation of cellular functions will be explored, as well as applications to pathophysiological states in disease.

Produktinformation

Utgivningsdatum2018-06-09
Mått155 x 235 x 18 mm
Vikt482 g
FormatHäftad
SpråkEngelska
SeriePhysiology in Health and Disease
Antal sidor302
FörlagSpringer-Verlag New York Inc.
ISBN9781493981663

Tillhör följande kategorier

Fysik inom Naturvetenskap och teknik
Kvantfysik inom Naturvetenskap och teknik
Biologi inom Naturvetenskap och teknik
Medicinsk utrustning och medicinska tekniker inom Medicin
Biokemi inom Naturvetenskap och teknik
Cellbiologi inom Naturvetenskap och teknik
Fysiologi inom Medicin

Part 1. Mechanosensors.- The Primary Cilium as a Strain Amplifying Microdomain for Mechanotransduction at the Cell Membrane.- Vascular Endothelial Mechanosensors in Response to Fluid Shear Stress.- Cadherins in Mechanotransduction.- Perspectives of FRET Imaging to study Epigenetics and Mechanobiology in the Nucleus.- Part 2. Transducers.- Emerging Roles of YAP/TAZ in Mechanobiology.- Role of Rho GTPases in Mechanobiology.- Illuminating Cell Adhesion: Modern Microscopy Approaches to Study Integrin-Based Focal Adhesions.- Part 3. Epigenetic and Genetic Regulations in the Nucleus.- Mechanotransduction to Epigenetic Remodeling.- The Nuclear Lamina: From Mechano-Sensing in Differentiation to Cancer Cell Migration.- Role of Cell Geometry on Nuclear Mechanics, Chromosome Reorganization, and Gene Expression.- Part 4. Applications.- Mechanobiological Control of Cell Fate for Applications in Cardiovascular Regenerative Medicine.- Heart Valve Mechanobiology in Development and Disease.- Molecular and Cellular Mechanobiology of Cancer.