ROBERT C. SMART, PhD, is a William Neal Reynolds Professor of Toxicology, the Director of the Center for Human Health and the Environment, and the former Director of the Toxicology Graduate Program at North Carolina State University. Together with Dr. Hodgson, he coedited the two previous editions of this book. ERNEST HODGSON, PhD, is Distinguished Professor Emeritus of Environmental and Molecular Toxicology and Executive Director of the Foundation for Agromedicine and Toxicology at North Carolina State University. Alongside the previous editions of this book, he edited four editions of A Textbook of Modern Toxicology (Wiley) and is the Editor of the Journal of Biochemical and Molecular Toxicology.

• Preface xxixList of Contributors xxxiSection 1 Introduction 11 Molecular and Biochemical Toxicology: Definition and Scope 3Ernest Hodgson and Robert C. SmartSection 2 Techniques in Biochemical and Molecular Toxicology 112 Molecular Techniques for the Study of Gene Function 13Yoshiaki Tsuji and Robert C. Smart3 Transcriptomics 55B. Alex Merrick4 Proteomics 91Michael S. Bereman5 Metabolomics 115Susan C. J. Sumner, Wimal Pathmasiri, James E. Carlson, Susan L. McRitchie, and Timothy R. Fennell6 Cellular Techniques 135Sharon A. Meyer and Barbara A. Wetmore7 Basic Concepts of Molecular Epidemiological Research Methods 159Cathrine Hoyo, David A. Skaar, and Randy L. JirtleSection 3 Mechanisms in Molecular and Biochemical Toxicology 1878 Phase I and Phase II Metabolism and Metabolic Interactions: A Summary 189Ernest Hodgson9 Structure, Mechanism, and Regulation of Cytochromes P 450 209John M. Seubert, Matthew L. Edin, and Darryl C. Zeldin10 Polymorphisms in Phase I and Phase II Genes and Outcomes 239Yoshiaki Tsuji, Edward L. Croom, and Ernest Hodgson11 Cellular Transport and Elimination 273David S. Miller and Ronald E. Cannon12 Nuclear Receptors 293Seth W. Kullman, William S. Baldwin, and Gerald A. LeBlanc13 Mechanisms of Cell Death 327Mac Law and Susan Elmore14 Mitochondrial Dysfunction 371Jun Ninomiya‐Tsuji15 Reactive Metabolites, Reactive Oxygen Species (ROS), and Toxicity 391Elizabeth L. MacKenzie and Yoshiaki Tsuji16 DNA Damage and Mutagenesis 421Zhigang Wang17 DNA Repair 485Isabel Mellon18 Carcinogenesis 535Robert C. Smart and Jonathan R. HallSection 4 Molecular and Biochemical Aspects of Organ Toxicology 58919 Molecular Mechanisms of Respiratory Toxicity 591James C. Bonner20 Molecular Mechanisms of Hepatotoxicity 629Supriya R. Kulkarni, Andrew D. Wallace, Sharon A. Meyer, and Angela L. Slitt21 Molecular Mechanisms of Renal Toxicology 665Lawrence H. Lash22 Molecular Mechanisms of Neurotoxicity 709Kimberly P. Keil, Marianna Stamou, and Pamela J. Lein23 Molecular Mechanisms of Immunotoxicity 773Tai L. Guo, Joella Xu, Yingjia Chen, Daniel E. Lefever, Guannan Huang, and David A. Lawrence24 Molecular Mechanisms of Reproductive Toxicity 823Ayelet Ziv‐Gal, Catheryne Chiang, and Jodi Anne Flaws25 Molecular Mechanisms of Developmental Toxicity 851Antonio PlanchartSection 5 Emerging Areas in Molecular and Biochemical Toxicology 87726 Computational and Molecular Approaches to Risk Assessment 879Richard S. Judson, John Wambaugh, Kristin Isaacs, and Russell S. Thomas27 Nanotoxicology 909James C. Bonner28 Developmental Origins of Health and Disease 933Michael Cowley29 Exposome 945Stephen M. RappaportIndex 969

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ROBERT C. SMART, PhD, is a William Neal Reynolds Professor of Toxicology, the Director of the Center for Human Health and the Environment, and the former Director of the Toxicology Graduate Program at North Carolina State University. Together with Dr. Hodgson, he coedited the two previous editions of this book. ERNEST HODGSON, PhD, is Distinguished Professor Emeritus of Environmental and Molecular Toxicology and Executive Director of the Foundation for Agromedicine and Toxicology at North Carolina State University. Alongside the previous editions of this book, he edited four editions of A Textbook of Modern Toxicology (Wiley) and is the Editor of the Journal of Biochemical and Molecular Toxicology.

• Preface xxixList of Contributors xxxiSection 1 Introduction 11 Molecular and Biochemical Toxicology: Definition and Scope 3Ernest Hodgson and Robert C. SmartSection 2 Techniques in Biochemical and Molecular Toxicology 112 Molecular Techniques for the Study of Gene Function 13Yoshiaki Tsuji and Robert C. Smart3 Transcriptomics 55B. Alex Merrick4 Proteomics 91Michael S. Bereman5 Metabolomics 115Susan C. J. Sumner, Wimal Pathmasiri, James E. Carlson, Susan L. McRitchie, and Timothy R. Fennell6 Cellular Techniques 135Sharon A. Meyer and Barbara A. Wetmore7 Basic Concepts of Molecular Epidemiological Research Methods 159Cathrine Hoyo, David A. Skaar, and Randy L. JirtleSection 3 Mechanisms in Molecular and Biochemical Toxicology 1878 Phase I and Phase II Metabolism and Metabolic Interactions: A Summary 189Ernest Hodgson9 Structure, Mechanism, and Regulation of Cytochromes P 450 209John M. Seubert, Matthew L. Edin, and Darryl C. Zeldin10 Polymorphisms in Phase I and Phase II Genes and Outcomes 239Yoshiaki Tsuji, Edward L. Croom, and Ernest Hodgson11 Cellular Transport and Elimination 273David S. Miller and Ronald E. Cannon12 Nuclear Receptors 293Seth W. Kullman, William S. Baldwin, and Gerald A. LeBlanc13 Mechanisms of Cell Death 327Mac Law and Susan Elmore14 Mitochondrial Dysfunction 371Jun Ninomiya‐Tsuji15 Reactive Metabolites, Reactive Oxygen Species (ROS), and Toxicity 391Elizabeth L. MacKenzie and Yoshiaki Tsuji16 DNA Damage and Mutagenesis 421Zhigang Wang17 DNA Repair 485Isabel Mellon18 Carcinogenesis 535Robert C. Smart and Jonathan R. HallSection 4 Molecular and Biochemical Aspects of Organ Toxicology 58919 Molecular Mechanisms of Respiratory Toxicity 591James C. Bonner20 Molecular Mechanisms of Hepatotoxicity 629Supriya R. Kulkarni, Andrew D. Wallace, Sharon A. Meyer, and Angela L. Slitt21 Molecular Mechanisms of Renal Toxicology 665Lawrence H. Lash22 Molecular Mechanisms of Neurotoxicity 709Kimberly P. Keil, Marianna Stamou, and Pamela J. Lein23 Molecular Mechanisms of Immunotoxicity 773Tai L. Guo, Joella Xu, Yingjia Chen, Daniel E. Lefever, Guannan Huang, and David A. Lawrence24 Molecular Mechanisms of Reproductive Toxicity 823Ayelet Ziv‐Gal, Catheryne Chiang, and Jodi Anne Flaws25 Molecular Mechanisms of Developmental Toxicity 851Antonio PlanchartSection 5 Emerging Areas in Molecular and Biochemical Toxicology 87726 Computational and Molecular Approaches to Risk Assessment 879Richard S. Judson, John Wambaugh, Kristin Isaacs, and Russell S. Thomas27 Nanotoxicology 909James C. Bonner28 Developmental Origins of Health and Disease 933Michael Cowley29 Exposome 945Stephen M. RappaportIndex 969

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ROBERT C. SMART, PhD, is a William Neal Reynolds Professor of Toxicology, the Director of the Center for Human Health and the Environment, and the former Director of the Toxicology Graduate Program at North Carolina State University. Together with Dr. Hodgson, he coedited the two previous editions of this book. ERNEST HODGSON, PhD, is Distinguished Professor Emeritus of Environmental and Molecular Toxicology and Executive Director of the Foundation for Agromedicine and Toxicology at North Carolina State University. Alongside the previous editions of this book, he edited four editions of A Textbook of Modern Toxicology (Wiley) and is the Editor of the Journal of Biochemical and Molecular Toxicology.

• Preface xxixList of Contributors xxxiSection 1 Introduction 11 Molecular and Biochemical Toxicology: Definition and Scope 3Ernest Hodgson and Robert C. SmartSection 2 Techniques in Biochemical and Molecular Toxicology 112 Molecular Techniques for the Study of Gene Function 13Yoshiaki Tsuji and Robert C. Smart3 Transcriptomics 55B. Alex Merrick4 Proteomics 91Michael S. Bereman5 Metabolomics 115Susan C. J. Sumner, Wimal Pathmasiri, James E. Carlson, Susan L. McRitchie, and Timothy R. Fennell6 Cellular Techniques 135Sharon A. Meyer and Barbara A. Wetmore7 Basic Concepts of Molecular Epidemiological Research Methods 159Cathrine Hoyo, David A. Skaar, and Randy L. JirtleSection 3 Mechanisms in Molecular and Biochemical Toxicology 1878 Phase I and Phase II Metabolism and Metabolic Interactions: A Summary 189Ernest Hodgson9 Structure, Mechanism, and Regulation of Cytochromes P 450 209John M. Seubert, Matthew L. Edin, and Darryl C. Zeldin10 Polymorphisms in Phase I and Phase II Genes and Outcomes 239Yoshiaki Tsuji, Edward L. Croom, and Ernest Hodgson11 Cellular Transport and Elimination 273David S. Miller and Ronald E. Cannon12 Nuclear Receptors 293Seth W. Kullman, William S. Baldwin, and Gerald A. LeBlanc13 Mechanisms of Cell Death 327Mac Law and Susan Elmore14 Mitochondrial Dysfunction 371Jun Ninomiya‐Tsuji15 Reactive Metabolites, Reactive Oxygen Species (ROS), and Toxicity 391Elizabeth L. MacKenzie and Yoshiaki Tsuji16 DNA Damage and Mutagenesis 421Zhigang Wang17 DNA Repair 485Isabel Mellon18 Carcinogenesis 535Robert C. Smart and Jonathan R. HallSection 4 Molecular and Biochemical Aspects of Organ Toxicology 58919 Molecular Mechanisms of Respiratory Toxicity 591James C. Bonner20 Molecular Mechanisms of Hepatotoxicity 629Supriya R. Kulkarni, Andrew D. Wallace, Sharon A. Meyer, and Angela L. Slitt21 Molecular Mechanisms of Renal Toxicology 665Lawrence H. Lash22 Molecular Mechanisms of Neurotoxicity 709Kimberly P. Keil, Marianna Stamou, and Pamela J. Lein23 Molecular Mechanisms of Immunotoxicity 773Tai L. Guo, Joella Xu, Yingjia Chen, Daniel E. Lefever, Guannan Huang, and David A. Lawrence24 Molecular Mechanisms of Reproductive Toxicity 823Ayelet Ziv‐Gal, Catheryne Chiang, and Jodi Anne Flaws25 Molecular Mechanisms of Developmental Toxicity 851Antonio PlanchartSection 5 Emerging Areas in Molecular and Biochemical Toxicology 87726 Computational and Molecular Approaches to Risk Assessment 879Richard S. Judson, John Wambaugh, Kristin Isaacs, and Russell S. Thomas27 Nanotoxicology 909James C. Bonner28 Developmental Origins of Health and Disease 933Michael Cowley29 Exposome 945Stephen M. RappaportIndex 969

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