Molecular and Applied Aspects of Oxidative Drug Metabolizing Enzymes

Häftad, Engelska, 2012

Av Emel Arinç, John B. Schenkman, Ernest Hodgson, Emel Arinc

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The NATO Advanced Study Institute of "Molecular and Applied Aspects of Oxida- tive Drug Metabolizing Enzymes" was held in Tekirova, Antalya, Turkey, from August 31 to September 11, 1997. This Institute was the third of a series of the NATO ASIs on a similar topic relating to the enzymes of oxidative metabolism of xenobiotics. The first NATO ASI in this series, entitled "Molecular Aspects of Monooxygenases and Bioactiva- tion of Toxic Compounds" (NATO ASI Series A: Life Sciences, Vol. 202), was held in

Produktinformation

Utgivningsdatum2012-10-08
Mått178 x 254 x 17 mm
Vikt583 g
SpråkEngelska
SerieNATO Science Series A:
Antal sidor294
FörlagSpringer-Verlag New York Inc.
EAN9781461372028

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1. The Fate of Xenobiotics in the Body: Enzymes of Metabolism.- 2. Protein-Protein Interactions in the P450 Monooxygenase System.- 3. Structures of Mitochondrial P450 System Proteins.- 4. Biochemical Aspects of Flavin-Containing Monooxygenases (FMOs).- 5. Expression and Regulation of Flavin-Containing Monooxygenases.- 6. Correlations between in Vivo and in Vitro Studies in Human Drug Metabolism.- 7. Pharmacogenetics: Polymorphisms in Xenobiotic Metabolism.- 8. Clinical Aspects of Polymorphic Drug Metabolism in Humans.- 9. Genetic Polymorphisms of Cytochromes P450 1 A1 and 2E1 and of Glutathione S-Transferase M1 and Cancer Susceptibility in the Human.- 10. Cytochrome P450 Isoforms: Insecticide Metabolism in Insects and Mammals and Role in Insecticide Resistance.- 11. Inhibitors of CYP51 as Antifungal Agents and Resistance to Azole Antifungals.- 12. The Role of Oxidative Drug Metabolizing Enzymes in Liver and Lung Specific Toxicity.- 13. Importance of Drug Metabolism in Drug Discovery and Development.- 14. Aflatoxin Biotransformation and Toxicology.- 15. Role of Individual Enzymes in the Control of Genotoxic Metabolites.- 16. Enhancement of the Mutagenicity of Ethylene Oxide and Several Directly Acting Mutagens by Human Erythrocytes and Its Reduction by Xenobiotic Interaction.- 17. Cytochrome P4501 Al (Cyp 1A1) and Associated MFO Activities in Fish as an Indicator of Pollution with Special Reference to Izmir Bay.- 18. Cyp 1A Concentrations as an Indicator of Exposure of Fish to Pulp-Mill Effluents.- 19. The Biochemistry and Physiology of Prostacyclin- and Thromboxane-Synthase.- 20. Cell Engineering of the Rat and Human Cysteine Conjugate Beta Lyase Genes and Applications to Nephrotoxicity Assessment.

Molecular and Applied Aspects of Oxidative Drug Metabolizing Enzymes

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