Modulation of Cardiac Calcium Sensitivity

A New Approach to Increasing the Strength of the Heart

Inbunden, Engelska, 1993

Av J. A. Lee, David G. Allen, UK) Lee, J. A. (Department of Pathology, Department of Pathology, University of Sheffield, Australia) Allen, David G. (Department of Physiology, Department of Physiology, University of Sydney

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The devlopment of calcium sensitizers represents the first major innovation in the treatment of heart failure for over 200 years. Unlike other drugs in this area, they do not increase the intracellular calcium concentration and do not have the side effects associated with that mechanism of action. These drugs offer an exciting alternative approach to the treatment of heart failure, and this volume provides an authoritative overview of the physiology, biochemistry, and clinical issues involved. It will be of particular interest to all those concerned with the treatment of heart failure.

Produktinformation

Utgivningsdatum1993-03-18
Mått156 x 234 x undefined mm
Vikt786 g
FormatInbunden
SpråkEngelska
Antal sidor360
FörlagOUP OXFORD
ISBN9780192623478

Tillhör följande kategorier

Hjärt- och kärlsjukdomar inom Medicin
Farmakologi inom Medicin

1. Altering the strength of the heart: basic mechanisms ; 2. In search of calcium sensitizer compounds: from subcellular models of music to in vivo positive intropic action ; 3. The influence of pH phosphate, and ionic strength of contraction in skinned cardiac muscle ; 4. The effects of acidosis on intact cardiac muscle ; 5. Natural calcium-sensitizing compounds of the heart ; 6. The effects of caffeine on cardiac muscle ; 7. Modulation of activation of cardiac myofilaments by beta-adrenergic agonists ; 8. Myosin light chain phosphorylation and myosin isoenzyme expression regulate cardiac calcium sensitivity by modulation of cross-bridge cycling kinetics ; 9. Changes in calcium sensitivity at the cross-bridge level ; 10. The genetic engineering and physiology of troponin C: molecular aspects of the modulation of cardiac calcium sensitivity ; 11. Analysis of the effects of drugs on myofibrillar Ca2+ sensitivity in intact cardiac muscle ; 12. Effects of anoxia and ischaemia on cardiac muscle ; 13. Changes in myofibrillar calcium responsiveness in the post-ischaemic heart (stunned myocardium) ; 14. Energetic aspects of altering myocardial sensitivity to calcium ; 15. Clinical experience with calcium sensitizers in congestive heart failure ; 16. Future directions ; Index