Modified Nucleic Acids in Biology and Medicine

Häftad, Engelska, 2018

AvStefan Jurga,Volker A. Erdmann (Deceased),Jan Barciszewski

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Furthermore, DNA damage can drive mutagenesis and the resulting DNA sequence changes can induce carcinogenesis and cancer progression.Modified nucleosides can occur as a result of oxidative DNA damage and RNA turnover, and are used as markers for various diseases.

Produktinformation

Utgivningsdatum2018-06-07
Mått155 x 235 x 26 mm
Vikt703 g
FormatHäftad
SpråkEngelska
SerieRNA Technologies
Antal sidor453
FörlagSpringer International Publishing AG
ISBN9783319816937

Tillhör följande kategorier

Medicinsk genetik inom Medicin
Biokemisk teknik inom Naturvetenskap och teknik
Biologi inom Naturvetenskap och teknik
Biokemi inom Naturvetenskap och teknik

Transfer RNA Modifications: from Biological Functions to Biomedical Applications.- Regulated tRNA Cleavage in Biology and Medicine: Roles of tRNA Modifications.- Sulfur-Modifications in tRNA: Function and Implications for Human Disease.- Regulation of Protein Synthesis via the Network Between Modified Nucleotides in tRNA and tRNA Modification Enzymes in Thermus thermophilus, Athermophilic Eubacterium.- Post-Transcriptional Modifications of RNA: Impact on RNA Function and Human Health.- RNA Modification N6-methyladenosine in Post-Transcriptional Regulation.- 8-Hydroxyguanine, an Oxidative DNA and RNA Modification.- Methods for Determination of 2’-O-Me in RNA.- DiadenosineTetraphosphate (Ap4A), in Health and Disease.- Thinking Small: Circulating MicroRNAs as Novel Biomarkers for Diagnosis, Prognosis and Treatment Monitoring in Breast Cancer.- Modified Antisense Oligonucleotides and their Analogs in Therapy of Neuromuscular Diseases.- Effect of Depurination on Cellular and Viral RNA.- Recognition of RNA Sequence and Structure by Duplex and Triplex Formation: Targeting miRNA and pre-miRNA.- Modifications in Therapeutic Oligonucleotides Improving the Delivery.- Interstrand Cross-Linking of Nucleic Acids: from History Towards Recent and Future Applications.- Chemical Synthesis of Lesion-Containing Oligonucleotides for DNA-Repair Studies.- Single-Molecule Visualization of Biomolecules in the Designed DNA Origami Nanostructures Using High-Speed Atomic Force Microscopy.- Polymerase Reactions that Involve Modified Nucleotides.