Models of Life

Dynamics and Regulation in Biological Systems

Inbunden, Engelska, 2014

AvKim Sneppen,Copenhagen) Sneppen, Kim (Niels Bohr Institutet

619 kr

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Reflecting the major advances that have been made in the field over the past decade, this book provides an overview of current models of biological systems. The focus is on simple quantitative models, highlighting their role in enhancing our understanding of the strategies of gene regulation and dynamics of information transfer along signalling pathways, as well as in unravelling the interplay between function and evolution. The chapters are self-contained, each describing key methods for studying the quantitative aspects of life through the use of physical models. They focus, in particular, on connecting the dynamics of proteins and DNA with strategic decisions on the larger scale of a living cell, using E. coli and phage lambda as key examples. Encompassing fields such as quantitative molecular biology, systems biology and biophysics, this book will be a valuable tool for students from both biological and physical science backgrounds.

Produktinformation

Utgivningsdatum2014-10-02
Mått180 x 253 x 20 mm
Vikt860 g
FormatInbunden
SpråkEngelska
Antal sidor350
FörlagCambridge University Press
ISBN9781107061903

Tillhör följande kategorier

Biovetenskap inom Naturvetenskap och teknik

Kim Sneppen is Professor of Physics at the Niels Bohr Institute and Director of the interdisciplinary Center for Models of Life (CMOL) at Copenhagen University, Denmark. Drawing on experience across several academic disciplines, his work explores the frontier between complex dynamical systems and living systems, and in his role at CMOL he promotes hands-on development of quantitative models of central biological processes. Sneppen is also co-author of Physics in Molecular Biology (Cambridge University Press, 2005).

Preface; 1. Life from a physics perspective; 2. E. coli as a model system; 3. Dynamics of regulatory links; 4. Statistical mechanics of phage λ; 5. Diffusion and randomness in transcription; 6. Stochastic genes and persistent decisions; 7. Gene regulation and epigenetics in cis; 8. Feedback circuits; 9. Networks; 10. Signalling and metabolic networks; 11. Agent-based models of signalling and selection; 12. Competition and diversity; 13. Evolution and extinction; Appendix; References; Index.

'Models of Life is an insight of a physicist into biological regulatory mechanisms. It provides a quantitative basis of how many of the biological systems work. Using simple logic and mathematics, Kim Sneppen, a world renowned scientist and thinker, has created a must-read for investigators in quantitative biology. The book provides a clear explanation of triumphant experiments in a lucid way with crisp figures. The brilliance of the author's analytical mind is on display when one sees how he explains some of the exciting paradigmatic regulatory systems, beginning with the basics of molecular biology. The book is also replete with intellectually challenging problem questions for readers, making the book an excellent text for students as well.' Sankar Adhya, National Cancer Institute, Maryland