This book constitutes the thoroughly refereed post-workshop proceedings of the 5th International Workshop on Modelling and Simulation for Autonomous Systems, MESAS 2018, held in Prague, Czech Republic, in October 2018.The 46 revised full papers included in the volume were carefully reviewed and selected from 66 submissions. They are organized in the following topical sections: Future Challenges of Advanced M&S Technology; Swarming - R&D and Application; M&S of Intelligent Systems - AI, R&D and Application; AxS in Context of Future Warfare and Security Environment (Concepts, Applications, Training, Interoperability, etc.).