This book constitutes the refereed proceedings of the 18th International Conference on Modeling Decisions for Artificial Intelligence, MDAI 2021, held in Umeå, Sweden, in September 2021.*The 24 papers presented in this volume were carefully reviewed and selected from 50 submissions. Additionally, 3 invited papers were included. The papers discuss different facets of decision processes in a broad sense and present research in data science, data privacy, aggregation functions, human decision making, graphs and social networks, and recommendation and search. The papers are organized in the following topical sections: aggregation operators and decision making; approximate reasoning; machine learning; data science and data privacy.*The conference was held virtually due to the COVID-19 pandemic.