This book constitutes the joint refereed proceedings of the Second International Conference on Modeling and Simulation of Social-Behavioral Phenomena in Creative Societies, MSBC 2022, held in Vilnius, Lithuania, in September 2022.The 14 full papers and 1 short paper presented were carefully reviewed and selected from 35 submissions. The papers are organized in the following topical sections: simulation of behavioral processes; modeling of sustainability; and data science and modeling.